Optical pH, oxygen and carbon dioxide monitoring using a microdialysis approach

Christopher G. Cooney, Bruce C. Towe, Curt R. Eyster

Research output: Contribution to journalArticlepeer-review

37 Scopus citations


Microdialysis coupled with optical absorbance or fluorescence measurement has been used to monitor pH, pCO2, and pO2 in blood and buffer solutions. The system employs micro-flow streams of reagents, a simple optical system and a method of achieving steady microliter per minute flow rates. When integrated in a recirculating flow loop, the sensor has an excellent resolution in the physiologic range in buffer of ±0.003 pH units, ±0.5 mm Hg pCO2, and ±1.5 mm Hg pO2 with response times in heparinized bovine blood of 4.8 min, 1.8 min, and 2.1 min for pH, pCO2, and pO2, respectively.

Original languageEnglish (US)
Pages (from-to)183-188
Number of pages6
JournalSensors and Actuators, B: Chemical
Issue number1
StatePublished - Sep 10 2000

ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials
  • Instrumentation
  • Condensed Matter Physics
  • Surfaces, Coatings and Films
  • Metals and Alloys
  • Electrical and Electronic Engineering
  • Materials Chemistry


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