TY - JOUR
T1 - Obesity and Obesity-Related Thyroid Dysfunction
T2 - Any Potential Role for the Very Low-Calorie Ketogenic Diet (VLCKD)?
AU - Chapela, Sebastián Pablo
AU - Simancas-Racines, Alison
AU - Ceriani, Florencia
AU - Martinuzzi, Andrés Luciano Nicolas
AU - Russo, María Paula
AU - Zambrano, Ana Karina
AU - Simancas-Racines, Daniel
AU - Verde, Ludovica
AU - Muscogiuri, Giovanna
AU - Katsanos, Christos S.
AU - Frias-Toral, Evelyn
AU - Barrea, Luigi
N1 - Publisher Copyright:
© The Author(s) 2024.
PY - 2024
Y1 - 2024
N2 - Purpose of Review: This review aims to explore in-depth the different aspects of the association between very low-calorie ketogenic diet (VLCKD), obesity and obesity-related thyroid dysfunction. Recent Findings: The VLCKD, proposed as a non-pharmacological strategy for the management of certain chronic diseases, is becoming increasingly popular worldwide. Initially used to treat epilepsy, it has been shown to be effective in controlling body weight gain and addressing various pathophysiological conditions. Research has shown that a low-calorie, high-fat diet can affect thyroid hormone levels. Weight loss can also influence thyroid hormone levels. Studies have suggested that long-term use of VLCKD for refractory epilepsy may be related to the development of hypothyroidism, with an effect seen in various populations. In particular, women with obesity following VLCKD tend to have reduced T3 levels. Summary: We propose further research to unravel the underlying mechanisms linking VLCKD to obesity and obesity-related thyroid dysfunction.
AB - Purpose of Review: This review aims to explore in-depth the different aspects of the association between very low-calorie ketogenic diet (VLCKD), obesity and obesity-related thyroid dysfunction. Recent Findings: The VLCKD, proposed as a non-pharmacological strategy for the management of certain chronic diseases, is becoming increasingly popular worldwide. Initially used to treat epilepsy, it has been shown to be effective in controlling body weight gain and addressing various pathophysiological conditions. Research has shown that a low-calorie, high-fat diet can affect thyroid hormone levels. Weight loss can also influence thyroid hormone levels. Studies have suggested that long-term use of VLCKD for refractory epilepsy may be related to the development of hypothyroidism, with an effect seen in various populations. In particular, women with obesity following VLCKD tend to have reduced T3 levels. Summary: We propose further research to unravel the underlying mechanisms linking VLCKD to obesity and obesity-related thyroid dysfunction.
KW - Hypothyroidism
KW - Obesity
KW - Thyrotropin
KW - Thyroxine
KW - Triiodothyronine
KW - Very low-calorie ketogenic diet
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U2 - 10.1007/s13668-024-00528-w
DO - 10.1007/s13668-024-00528-w
M3 - Review article
AN - SCOPUS:85188540779
SN - 2161-3311
JO - Current Nutrition Reports
JF - Current Nutrition Reports
ER -