Novel Method & Materials for Advanced Tumor Imaging

Ana Moore (Inventor), Thomas Moore (Inventor)

Research output: Patent


Tissue/tumor imaging for diagnostic purposes has been an important focus of researchers across the country, who are continually searching for better imaging methods as well as new imaging agents. Not only may such agents allow for better surgical precision but may also provide future opportunities for non-surgical therapeutics as well. Porphyrin-based compounds are commonly used for imaging, detection and diagnosis of tissues, however, the major drawback with them includes collateral photodamage to healthy tissue. Researchers at Arizona State University have developed a platform of novel technologies and know-how regarding photoidentification of target tissue using imaging materials that fluoresce or phosphoresce upon exposure to electromagnetic radiation. The emission can be detected via spectroscopy or heat detection by various calorimetric methods. This allows for precise identification of the location, size and shape of the target tissue, primarily tumors. Two particularly unique features of these technologies include high sensitivity and lack of photodamage or production of singlet oxygen (by quenching the excited triplet state of the imaging agent). Moreover, photopenetration of the tissue by excitation light and by emitted light is enhanced by the use of agents that absorb and emit lower energy (longer wavelength) electromagnetic radiation. This novel suite of technologies, which alleviate many drawbacks to conventional imaging modalities, provides a unique and safe alternative to allow for sensitive tumor/tissue imaging and diagnosis. Potential Applications Tissue imaging Tumors Atherosclerotic and arthritic tissue Diseased blood vessels Mammalian pathologyAdjunctive to surgery as a means to define tissue to be removed MRI, X-ray or other high energy radiation contrast agent Benefits and Advantages Safe - doesn't cause collateral photodamage to surrounding healthy tissue or promote singlet oxygen formation High sensitivity Utilizes longer wavelength excitation light to promote deeper tissue penetration Low toxicity - due to the antioxidant behavior of the auxiliary chromophore May be used in conjunction with other conventional imaging modalitiesDownload Original PDF For more information about the inventor(s) and their research, please see Dr. Ana Moore's laboratory webpageDr. Thomas Moore's laboratory webpageDr. Gust's laboratory webpage
Original languageEnglish (US)
StatePublished - Jul 21 1997


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