@inproceedings{12c32f4dd3b54453ac5ede08c79f2ac3,
title = "Novel high-throughput screening system for cancer therapy with simultaneous combination treatments",
abstract = "In this paper, we report the development of a microfluidic high-throughput screening system for high-throughput screening of drug molecule interactions on cancer cell death. A key feature is that 64 pair-wise concentrations (between eight concentrations of two drugs) are generated using a traditional diffusive microfluidic mixer and a time-dependent variable concentration mixer. Using this novel high-throughput combination array, we generated pair-wise combinations of the cancer drug sensitizer doxorubicin and the cytokine TRAIL, and used it for on-chip screening against PC3 prostate cancer cells. Our results identify a concentration range where doxorubicin and TRAIL are synergistic and demonstrates the utility of the system as a high-throughput anti-cancer drug screening tool.",
keywords = "Combination treatment, Doxorubicin, High-throughput screening, Prostate cancer, TRAIL",
author = "Kim, {J. Y.} and D. Taylor and Kaushal Rege and Kim, {H. S.} and Han, {A. R.} and A. Jayaraman",
year = "2010",
language = "English (US)",
isbn = "9781618390622",
series = "14th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2010, MicroTAS 2010",
pages = "836--838",
booktitle = "14th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2010, MicroTAS 2010",
note = "14th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2010, MicroTAS 2010 ; Conference date: 03-10-2010 Through 07-10-2010",
}