Novel electrospun pullulan fibers incorporating hydroxypropyl-β-cyclodextrin: Morphology and relation with rheological properties

Deepak Poudel, Sarah Swilley-Sanchez, Sean O’keefe, John Matson, Timothy Long, Cristina Fernández-Fraguas

Research output: Contribution to journalArticlepeer-review

9 Scopus citations


Fibers produced by electrospinning from biocompatible, biodegradable and naturally occurring polymers have potential advantages in drug delivery and biomedical applications because of their unique functionalities. Here, electrospun submicron fibers were produced from mixtures containing an exopolysaccharide (pullulan) and a small molecule with hosting abilities, hydroxypropyl-β-cyclodextrin (HP-β-CD), thus serving as multi-functional blend. The procedure used water as sole solvent and excluded synthetic polymers. Rheological characterization was performed to evaluate the impact of HP-β-CD on pullulan entanglement concentration (CE); the relationship with electrospinnability and fiber morphology was investigated. Neat pullulan solutions required three times CE (~20% w/v pullulan) for effective electrospinning and formation of bead-free nanofibers. HP-β-CD (30% w/v) facilitated electrospinning, leading to the production of continuous, beadless fibers (average diameters: 853-1019 nm) at lower polymer concentrations than those required in neat pullulan systems, without significantly shifting the polymer CE. Rheological, Differential Scanning Calorimetry (DSC) and Dynamic Light Scattering (DLS) measurements suggested that electrospinnability improvement was due to HP-β-CD assisting in pullulan entanglement, probably acting as a crosslinker. Yet, the type of association was not clearly identified. This study shows that blending pullulan with HP-β-CD offers a platform to exploit the inherent properties and advantages of both components in encapsulation applications.

Original languageEnglish (US)
Article number2558
Pages (from-to)1-20
Number of pages20
Issue number11
StatePublished - Nov 2020
Externally publishedYes


  • Electrospinning
  • Entanglement concentration
  • Hydroxypropyl-β-cyclodextrin
  • Pullulan
  • Rheology

ASJC Scopus subject areas

  • Chemistry(all)
  • Polymers and Plastics


Dive into the research topics of 'Novel electrospun pullulan fibers incorporating hydroxypropyl-β-cyclodextrin: Morphology and relation with rheological properties'. Together they form a unique fingerprint.

Cite this