Nitric oxide: a new concept in chronic sinusitis pathogenesis

Mohsen Naraghi, Armin Farajzadeh Deroee, Mohammad Reza Ebrahimkhani, Samira Kiani, Ahmad Reza Dehpour

Research output: Contribution to journalArticlepeer-review

36 Scopus citations


Purpose: Exhaled NO is produced mainly in paranasal sinuses and nasal mucosa. Nasal NO has been suggested to have a variety of effects in nasal cavity. Decreased exhaled NO is found in chronic sinusitis, and NO metabolite levels are increased in animal models of chronic sinusitis, suggesting a role for them in sinusitis pathogenesis. There was no data available on human NO metabolite level. Materials and methods: We lavaged maxillary sinuses in a control and 2 patient groups. The control group was patients who underwent functional endoscopic sinus surgery (FESS) due to any other reason than chronic sinusitis. The patient groups had chronic rhinosinusitis with and without polyposis who underwent FESS. Maxillary sinuses were lavaged during FESS, and NO metabolites (nitrate and nitrite) were lavaged in the lavage fluid. Results: Nitric oxide metabolite levels (mean ± SEM) were 8.085 ± 1.43 μmol/L in healthy maxillary sinus lavage fluid and 18.04 ± 3.51 and 16.78 ± 2.91 μmol/L in chronic rhinosinusitis with and without polyposis, respectively. Lavage fluid of sinuses with chronic sinusitis had elevated levels of NO metabolites, which were significantly higher than the control group. The difference between the chronic sinusitis with and without polyposis groups was not significant. Conclusions: Nitric oxide metabolites were significantly higher in maxillary sinuses of patients with chronic sinusitis. Elevated levels of NO and NO metabolites in sinusitis might damage healthy sinus epithelium. NO metabolites may have an important role in sinusitis pathogenesis.

Original languageEnglish (US)
Pages (from-to)334-337
Number of pages4
JournalAmerican Journal of Otolaryngology - Head and Neck Medicine and Surgery
Issue number5
StatePublished - Sep 2007
Externally publishedYes

ASJC Scopus subject areas

  • Otorhinolaryngology


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