TY - JOUR
T1 - Nicotine-induced place conditioning and locomotor activity in an adolescent animal model of attention deficit/hyperactivity disorder (ADHD)
AU - Watterson, Elizabeth
AU - Daniels, Carter W.
AU - Watterson, Lucas R.
AU - Mazur, Gabriel J.
AU - Brackney, Ryan J.
AU - Olive, Michael
AU - Sanabria, Federico
N1 - Funding Information:
This research was supported by a seed grant from the College of Liberal Arts and Sciences, Arizona State University , and two grants from the National Institutes of Health ( DA032632 , MH094562 ). The authors thank Janet Neisewander and Laurie Chassin for providing feedback to early drafts of this manuscript.
Publisher Copyright:
© 2015 Elsevier B.V.
PY - 2015/9/5
Y1 - 2015/9/5
N2 - Attention deficit/hyperactivity disorder (ADHD) is a risk factor for tobacco use and dependence. This study examines the responsiveness to nicotine of an adolescent model of ADHD, the spontaneously hypertensive rat (SHR). The conditioned place preference (CPP) procedure was used to assess nicotine-induced locomotion and conditioned reward in SHR and the Wistar Kyoto (WKY) control strain over a range of nicotine doses (0.0, 0.1, 0.3 and 0.6. mg/kg). Prior to conditioning, SHRs were more active and less biased toward one side of the CPP chamber than WKY rats. Following conditioning, SHRs developed CPP to the highest dose of nicotine (0.6. mg/kg), whereas WKYs did not develop CPP to any nicotine dose tested. During conditioning, SHRs displayed greater locomotor activity in the nicotine-paired compartment than in the saline-paired compartment across conditioning trials. SHRs that received nicotine (0.1, 0.3, 0.6. mg/kg) in the nicotine-paired compartment showed an increase in locomotor activity between conditioning trials. Nicotine did not significantly affect WKY locomotor activity. These findings suggest that the SHR strain is a suitable model for studying ADHD-related nicotine use and dependence, but highlights potential limitations of the WKY control strain and the CPP procedure for modeling ADHD-related nicotine reward.
AB - Attention deficit/hyperactivity disorder (ADHD) is a risk factor for tobacco use and dependence. This study examines the responsiveness to nicotine of an adolescent model of ADHD, the spontaneously hypertensive rat (SHR). The conditioned place preference (CPP) procedure was used to assess nicotine-induced locomotion and conditioned reward in SHR and the Wistar Kyoto (WKY) control strain over a range of nicotine doses (0.0, 0.1, 0.3 and 0.6. mg/kg). Prior to conditioning, SHRs were more active and less biased toward one side of the CPP chamber than WKY rats. Following conditioning, SHRs developed CPP to the highest dose of nicotine (0.6. mg/kg), whereas WKYs did not develop CPP to any nicotine dose tested. During conditioning, SHRs displayed greater locomotor activity in the nicotine-paired compartment than in the saline-paired compartment across conditioning trials. SHRs that received nicotine (0.1, 0.3, 0.6. mg/kg) in the nicotine-paired compartment showed an increase in locomotor activity between conditioning trials. Nicotine did not significantly affect WKY locomotor activity. These findings suggest that the SHR strain is a suitable model for studying ADHD-related nicotine use and dependence, but highlights potential limitations of the WKY control strain and the CPP procedure for modeling ADHD-related nicotine reward.
KW - Adolescence
KW - Attention deficit/hyperactivity disorder (ADHD)
KW - Locomotor Behavior
KW - Nicotine
KW - Reward
KW - Spontaneously hypertensive rat (SHR)
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U2 - 10.1016/j.bbr.2015.05.031
DO - 10.1016/j.bbr.2015.05.031
M3 - Article
C2 - 26008156
AN - SCOPUS:84930628217
SN - 0166-4328
VL - 291
SP - 184
EP - 188
JO - Behavioural Brain Research
JF - Behavioural Brain Research
ER -