NGF and Alzheimer's disease: Unfulfilled promise and untapped potential

Jeffrey H. Kordower; Elliott J. Mufson

doi:10.1016/0197-4580(89)90123-1

NGF and Alzheimer's disease: Unfulfilled promise and untapped potential

Jeffrey H. Kordower, Elliott J. Mufson

Research output: Contribution to journal › Article › peer-review

14 Scopus citations

Abstract

A role for impaired NGF mechanisms as an underlying component in the pathogenesis of Alzheimer's disease has yet to be realized. However, circumspect examination of the available data fails to provide sufficient evidence for rejecting this notion and further systematic evaluation along each step of NGF's mechanism of neurotrophic action is still required. This commentary argues that NGF may be involved in the degeneration observed in the basal forebrain in AD, or at the very least, plays a dynamic role in the disease process.

Original language	English (US)
Pages (from-to)	543-544
Number of pages	2
Journal	Neurobiology of Aging
Volume	10
Issue number	5
DOIs	https://doi.org/10.1016/0197-4580(89)90123-1
State	Published - 1989
Externally published	Yes

ASJC Scopus subject areas

Neuroscience(all)
Aging
Clinical Neurology
Developmental Biology
Geriatrics and Gerontology

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abstract = "A role for impaired NGF mechanisms as an underlying component in the pathogenesis of Alzheimer's disease has yet to be realized. However, circumspect examination of the available data fails to provide sufficient evidence for rejecting this notion and further systematic evaluation along each step of NGF's mechanism of neurotrophic action is still required. This commentary argues that NGF may be involved in the degeneration observed in the basal forebrain in AD, or at the very least, plays a dynamic role in the disease process.",

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AB - A role for impaired NGF mechanisms as an underlying component in the pathogenesis of Alzheimer's disease has yet to be realized. However, circumspect examination of the available data fails to provide sufficient evidence for rejecting this notion and further systematic evaluation along each step of NGF's mechanism of neurotrophic action is still required. This commentary argues that NGF may be involved in the degeneration observed in the basal forebrain in AD, or at the very least, plays a dynamic role in the disease process.

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NGF and Alzheimer's disease: Unfulfilled promise and untapped potential

Abstract

ASJC Scopus subject areas

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