Nanoindentation of Pseudomonas aeruginosa bacterial biofilm using atomic force microscopy

Mahmoud Baniasadi, Zhe Xu, Leah Gandee, Yingjie Du, Hongbing Lu, Philippe Zimmern, Majid Minary-Jolandan

Research output: Contribution to journalArticlepeer-review

28 Scopus citations


Bacterial biofilms are a source of many chronic infections. Biofilms and their inherent resistance to antibiotics are attributable to a range of health issues including affecting prosthetic implants, hospital-acquired infections, and wound infection. Mechanical properties of biofilm, in particular, at micro- and nanoscales, are governed by microstructures and porosity of the biofilm, which in turn may contribute to their inherent antibiotic resistance. We utilize atomic force microscopy (AFM)-based nanoindentation and finite element simulation to investigate the nanoscale mechanical properties of Pseudomonas aeruginosa bacterial biofilm. This biofilm was derived from human samples and represents a medically relevant model.

Original languageEnglish (US)
Article number045411
JournalMaterials Research Express
Issue number4
StatePublished - Dec 2015
Externally publishedYes


  • Atomic force microscope
  • Bacterial biofilm
  • Nanoindentation
  • Nanomechanical properties
  • Pseudomonas aeruginosa

ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials
  • Biomaterials
  • Surfaces, Coatings and Films
  • Polymers and Plastics
  • Metals and Alloys


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