Nanoencapsulation enhances epigallocatechin-3-gallate stability and its antiatherogenic bioactivities in macrophages

Jia Zhang, Shufang Nie, Shu Wang

Research output: Contribution to journalArticlepeer-review

72 Scopus citations


We have successfully synthesized (-)-epigallocatechin-3-gallate (EGCG) encapsulated nanostructured lipid carriers (NLCE) and chitosan-coated NLCE (CSNLCE) using natural lipids, surfactant, chitosan, and EGCG. Nanoencapsulation dramatically improved EGCG stability. CSNLCE significantly increased EGCG content in THP-1-derived macrophages compared with nonencapsulated EGCG. As compared to 10 μM nonencapsulated EGCG, both NLCE and CSNLCE at the same concentration significantly decreased macrophage cholesteryl ester content. NLCE and CSNLCE significantly decreased mRNA levels and protein secretion of monocyte chemoattractant protein-1 (MCP-1) levels in macrophages, respectively. These data suggest that nanoencapsulated EGCG may have a potential to inhibit atherosclerotic lesion development through decreasing macrophage cholesterol content and MCP-1 expression.

Original languageEnglish (US)
Pages (from-to)9200-9209
Number of pages10
JournalJournal of Agricultural and Food Chemistry
Issue number38
StatePublished - Sep 25 2013
Externally publishedYes


  • EGCG
  • atherosclerosis
  • macrophage
  • nanostructured lipid carriers
  • stability
  • uptake

ASJC Scopus subject areas

  • General Chemistry
  • General Agricultural and Biological Sciences


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