Abstract
N-Substituted 2-amino-4-pentenoic acid derivatives employed for the protection of racemic amino acids were shown to be capable of permitting the chromatographic separation of R and S isomers. When N(α) was disubstituted with benzyl and phenylfluorenyl groups, the racemic amino acids could be separated with facility on open silica gel columns. Further, the optically pure N-protected amino acids so derived could be used for the preparation of misacylated suppressor transfer RNAs. (C) 2000 Elsevier Science Ltd.
Original language | English (US) |
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Pages (from-to) | 9421-9429 |
Number of pages | 9 |
Journal | Tetrahedron |
Volume | 56 |
Issue number | 48 |
DOIs | |
State | Published - Nov 24 2000 |
Externally published | Yes |
Keywords
- Amino acids and derivatives
- Optical properties
- Protecting groups
- Resolution
ASJC Scopus subject areas
- Biochemistry
- Drug Discovery
- Organic Chemistry