Myxoma virus in the European rabbit: Interactions between the virus and its susceptible host

Marianne M. Stanford; Steven J. Werden; Grant McFadden

doi:10.1051/vetres:2006054

Myxoma virus in the European rabbit: Interactions between the virus and its susceptible host

Marianne M. Stanford, Steven J. Werden, Grant McFadden

Research output: Contribution to journal › Review article › peer-review

80 Scopus citations

Abstract

Myxoma virus (MV) is a poxvirus that evolved in Sylvilagus lagomorphs, and is the causative agent of myxomatosis in European rabbits (Oryctolagus cuniculus). This virus is not a natural pathogen of O. cuniculus, yet is able to subvert the host rabbit immune system defenses and cause a highly lethal systemic infection. The interaction of MV proteins and the rabbit immune system has been an ideal model to help elucidate host/poxvirus interactions, and has led to a greater understanding of how other poxvirus pathogens are able to cause disease in their respective hosts. This review will examine how MV causes myxomatosis, by examining a selection of the identified immunomodulatory proteins that this virus expresses to subvert the immune and inflammatory pathways of infected rabbit hosts.

Original language	English (US)
Pages (from-to)	299-318
Number of pages	20
Journal	Veterinary Research
Volume	38
Issue number	2
DOIs	https://doi.org/10.1051/vetres:2006054
State	Published - Mar 2007
Externally published	Yes

Keywords

Immunomodulation
Myxoma virus
Oryctolagus cuniculus
Poxvirus

ASJC Scopus subject areas

General Veterinary

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10.1051/vetres:2006054

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title = "Myxoma virus in the European rabbit: Interactions between the virus and its susceptible host",

abstract = "Myxoma virus (MV) is a poxvirus that evolved in Sylvilagus lagomorphs, and is the causative agent of myxomatosis in European rabbits (Oryctolagus cuniculus). This virus is not a natural pathogen of O. cuniculus, yet is able to subvert the host rabbit immune system defenses and cause a highly lethal systemic infection. The interaction of MV proteins and the rabbit immune system has been an ideal model to help elucidate host/poxvirus interactions, and has led to a greater understanding of how other poxvirus pathogens are able to cause disease in their respective hosts. This review will examine how MV causes myxomatosis, by examining a selection of the identified immunomodulatory proteins that this virus expresses to subvert the immune and inflammatory pathways of infected rabbit hosts.",

keywords = "Immunomodulation, Myxoma virus, Oryctolagus cuniculus, Poxvirus",

author = "Stanford, {Marianne M.} and Werden, {Steven J.} and Grant McFadden",

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AU - Werden, Steven J.

AU - McFadden, Grant

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N2 - Myxoma virus (MV) is a poxvirus that evolved in Sylvilagus lagomorphs, and is the causative agent of myxomatosis in European rabbits (Oryctolagus cuniculus). This virus is not a natural pathogen of O. cuniculus, yet is able to subvert the host rabbit immune system defenses and cause a highly lethal systemic infection. The interaction of MV proteins and the rabbit immune system has been an ideal model to help elucidate host/poxvirus interactions, and has led to a greater understanding of how other poxvirus pathogens are able to cause disease in their respective hosts. This review will examine how MV causes myxomatosis, by examining a selection of the identified immunomodulatory proteins that this virus expresses to subvert the immune and inflammatory pathways of infected rabbit hosts.

AB - Myxoma virus (MV) is a poxvirus that evolved in Sylvilagus lagomorphs, and is the causative agent of myxomatosis in European rabbits (Oryctolagus cuniculus). This virus is not a natural pathogen of O. cuniculus, yet is able to subvert the host rabbit immune system defenses and cause a highly lethal systemic infection. The interaction of MV proteins and the rabbit immune system has been an ideal model to help elucidate host/poxvirus interactions, and has led to a greater understanding of how other poxvirus pathogens are able to cause disease in their respective hosts. This review will examine how MV causes myxomatosis, by examining a selection of the identified immunomodulatory proteins that this virus expresses to subvert the immune and inflammatory pathways of infected rabbit hosts.

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KW - Oryctolagus cuniculus

KW - Poxvirus

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Myxoma virus in the European rabbit: Interactions between the virus and its susceptible host

Abstract

Keywords

ASJC Scopus subject areas

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