Missing pieces in the Parkinson's disease puzzle

Jose A. Obeso, Maria C. Rodriguez-Oroz, Christopher G. Goetz, Concepcion Marin, Jeffrey H. Kordower, Manuel Rodriguez, Etienne C. Hirsch, Matthew Farrer, Anthony H.V. Schapira, Glenda Halliday

Research output: Contribution to journalReview articlepeer-review

576 Scopus citations


Parkinson's disease is a neurodegenerative process characterized by numerous motor and nonmotor clinical manifestations for which effective, mechanism-based treatments remain elusive. Here we discuss a series of critical issues that we think researchers need to address to stand a better chance of solving the different challenges posed by this pathology.

Original languageEnglish (US)
Pages (from-to)653-661
Number of pages9
JournalNature Medicine
Issue number6
StatePublished - Jun 2010
Externally publishedYes

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)


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