TY - GEN
T1 - Miniaturized silicon apertures for lipid bilayer reconstitution experiments
AU - Goryll, Michael
AU - Chaplot, Nipun
PY - 2009
Y1 - 2009
N2 - Ion channels reconstituted into lipid bilayer membranes can be used as a very sensitive and selective platform for high-throughput drug screening applications. In order to employ suspended lipid bilayer membranes for these experiments in form of a "lab-on-a-chip" configuration, a robust and affordable platform is required. In our study, we investigated the feasibility of hosting lipid bilayer membranes across micron-size apertures ranging from 5 μm - 50 μm in silicon. On these substrates, lipid bilayers were formed and characterized concerning their seal resistance, capacitance and breakdown voltage. Seal resistance values of up to 60 GΩ could be achieved repeatedly on these substrates.
AB - Ion channels reconstituted into lipid bilayer membranes can be used as a very sensitive and selective platform for high-throughput drug screening applications. In order to employ suspended lipid bilayer membranes for these experiments in form of a "lab-on-a-chip" configuration, a robust and affordable platform is required. In our study, we investigated the feasibility of hosting lipid bilayer membranes across micron-size apertures ranging from 5 μm - 50 μm in silicon. On these substrates, lipid bilayers were formed and characterized concerning their seal resistance, capacitance and breakdown voltage. Seal resistance values of up to 60 GΩ could be achieved repeatedly on these substrates.
UR - http://www.scopus.com/inward/record.url?scp=77649102336&partnerID=8YFLogxK
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U2 - 10.1557/proc-1191-oo08-05
DO - 10.1557/proc-1191-oo08-05
M3 - Conference contribution
AN - SCOPUS:77649102336
SN - 9781605111292
SN - 9781605111643
T3 - Materials Research Society Symposium Proceedings
SP - 79
EP - 84
BT - Materials and Strategies for Lab-on-a-Chip - Biological Analysis, Cell-Material Interfaces and Fluidic Assembly of Nanostructures
PB - Materials Research Society
T2 - 2009 MRS Spring Meeting
Y2 - 13 April 2009 through 17 April 2009
ER -