Microsatellite markers for standardized genetic management of captive colonies of rhesus macaques (Macaca mulatta)

Sreetharan Kanthaswamy, Andrea Von Dollen, Jennifer D. Kurushima, Ona Alminas, Jeffrey Rogers, Betsy Ferguson, Nicholas W. Lerche, Philip C. Allen, David Glenn Smith

Research output: Contribution to journalArticlepeer-review

44 Scopus citations


To preserve genetic variability and minimize genetic subdivision among captive Macaca, mulatta at each of the U.S. National Institutes of Health (NIH)-sponsored regional research colonies, the genetic structure of each colony must be characterized. To compare population genetic and demographic parameters across colonies and generations, one standard panel of highly informative genetic markers is required. We assembled a core marker set of four multiplex polymerase chain reaction (PCR) panels comprising 15 autosomal short tandem repeat (STR) loci with high information content selected from existing panels of well-characterized markers that are currently used for parentage assessment and genetic management of rhesus macaques. We then assessed the effectiveness of these loci for providing high probabilities of individual identification and parentage resolution, and for estimating population genetic parameters that are useful for genetic management.

Original languageEnglish (US)
Pages (from-to)73-95
Number of pages23
JournalAmerican Journal of Primatology
Issue number1
StatePublished - Jan 2006
Externally publishedYes


  • Genetic diversity
  • Heterozygosity
  • Polymorphic information content (PIC)
  • Probability of genetic identity (PI)
  • Probability of parentage exclusion (PE)
  • Short tandem repeats (STRs)

ASJC Scopus subject areas

  • Ecology, Evolution, Behavior and Systematics
  • Animal Science and Zoology


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