Microelectrode array (MEA) platform for targeted neuronal transfection and recording

Research output: Contribution to journalArticlepeer-review

16 Scopus citations


Techniques used for nonviral gene transfection often have poor spatial resolution. In this letter, we present a microelectrode array (MEA) system that can precisely transfect exogenous molecules into targeted primary neurons using microelectroporation. An optimal cathodic pulse 4 V in amplitude and 1 ms in duration resulted in a transfection efficiency of 56% and a viability of 82%. Finally, siRNA molecules were transfected into targeted neurons in culture using the aforementioned system.

Original languageEnglish (US)
Pages (from-to)827-832
Number of pages6
JournalIEEE Transactions on Biomedical Engineering
Issue number2
StatePublished - Feb 2008


  • Biochip
  • Electroporation
  • Transfection
  • siRNA

ASJC Scopus subject areas

  • Biomedical Engineering


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