Abstract
Two novel approaches have been employed for mediating RNA strand scission under physiological conditions. One of these involved strand scission by an Fe2+ chelate of the antitumor antibiotic bleomycin; the other involved a novel Mn2+-dependent cleavage of an RNA hairpin at a specific site. Bleomycin-mediated RNA cleavage was oxidative in nature, while the Mn2+-promoted cleavage of the hairpin occurred by a solvolytic mechanism.
Original language | English (US) |
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Pages (from-to) | 215-227 |
Number of pages | 13 |
Journal | Nucleosides and Nucleotides |
Volume | 10 |
Issue number | 1-3 |
DOIs | |
State | Published - Jan 1 1991 |
Externally published | Yes |
ASJC Scopus subject areas
- Biochemistry
- Genetics