Mediation designs for tobacco prevention research

David Mackinnon, Marcia P. Taborga, Antonio A. Morgan-Lopez

Research output: Contribution to journalArticlepeer-review

101 Scopus citations


This paper describes research designs and statistical analyses to investigate how tobacco prevention programs achieve their effects on tobacco use. A theoretical approach to program development and evaluation useful for any prevention program guides the analysis. The theoretical approach focuses on action theory for how the program affects mediating variables and on conceptual theory for how mediating variables are related to tobacco use. Information on the mediating mechanisms by which tobacco prevention programs achieve effects is useful for the development of efficient programs and provides a test of the theoretical basis of prevention efforts. Examples of these potential mediating mechanisms are described including mediated effects through attitudes, social norms, beliefs about positive consequences, and accessibility to tobacco. Prior research provides evidence that changes in social norms are a critical mediating mechanism for successful tobacco prevention. Analysis of mediating variables in single group designs with multiple mediators are described as well as multiple group randomized designs which are the most likely to accurately uncover important mediating mechanisms. More complicated dismantling and constructive designs are described and illustrated based on current findings from tobacco research. Mediation analysis for categorical outcomes and more complicated statistical methods are outlined.

Original languageEnglish (US)
Pages (from-to)69-83
Number of pages15
JournalDrug and alcohol dependence
StatePublished - Nov 1 2002


  • Adolescents
  • Indirect effects
  • Mediation
  • Methodology
  • Prevention
  • Tobacco

ASJC Scopus subject areas

  • Toxicology
  • Pharmacology
  • Psychiatry and Mental health
  • Pharmacology (medical)


Dive into the research topics of 'Mediation designs for tobacco prevention research'. Together they form a unique fingerprint.

Cite this