Marine sesquiterpenoids that inhibit the lyase activity of DNA polymerase β

Shugeng Cao; Zhijie Gao; Shannon J. Thomas; Sidney M. Hecht; John S. Lazo; David G.I. Kingston

doi:10.1021/np049849+

Marine sesquiterpenoids that inhibit the lyase activity of DNA polymerase β

Shugeng Cao, Zhijie Gao, Shannon J. Thomas, Sidney M. Hecht, John S. Lazo, David G.I. Kingston

Research output: Contribution to journal › Article › peer-review

26 Scopus citations

Abstract

Bioassay-directed fractionation of an extract of the marine species Spongia sp. led to the discovery of the new sesquiterpenoid derivative 17-O-isoprenyldictyoceratin-C (1), the known sesquiterpenoid derivative dictyoceratin-C (2), and the sesquiterpenoid quinone ilimaquinone (3), in addition to the nucleoside 2′-deoxyuridine. The structure of the new compound 1 was determined on the basis of spectroscopic methods and by conversion of dictyoceratin-C (2) to 1.

Original language	English (US)
Pages (from-to)	1716-1718
Number of pages	3
Journal	Journal of Natural Products
Volume	67
Issue number	10
DOIs	https://doi.org/10.1021/np049849+
State	Published - Oct 2004
Externally published	Yes

ASJC Scopus subject areas

Analytical Chemistry
Molecular Medicine
Pharmacology
Pharmaceutical Science
Drug Discovery
Complementary and alternative medicine
Organic Chemistry

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title = "Marine sesquiterpenoids that inhibit the lyase activity of DNA polymerase β",

abstract = "Bioassay-directed fractionation of an extract of the marine species Spongia sp. led to the discovery of the new sesquiterpenoid derivative 17-O-isoprenyldictyoceratin-C (1), the known sesquiterpenoid derivative dictyoceratin-C (2), and the sesquiterpenoid quinone ilimaquinone (3), in addition to the nucleoside 2′-deoxyuridine. The structure of the new compound 1 was determined on the basis of spectroscopic methods and by conversion of dictyoceratin-C (2) to 1.",

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AU - Cao, Shugeng

AU - Gao, Zhijie

AU - Thomas, Shannon J.

AU - Hecht, Sidney M.

AU - Lazo, John S.

AU - Kingston, David G.I.

PY - 2004/10

Y1 - 2004/10

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AB - Bioassay-directed fractionation of an extract of the marine species Spongia sp. led to the discovery of the new sesquiterpenoid derivative 17-O-isoprenyldictyoceratin-C (1), the known sesquiterpenoid derivative dictyoceratin-C (2), and the sesquiterpenoid quinone ilimaquinone (3), in addition to the nucleoside 2′-deoxyuridine. The structure of the new compound 1 was determined on the basis of spectroscopic methods and by conversion of dictyoceratin-C (2) to 1.

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Marine sesquiterpenoids that inhibit the lyase activity of DNA polymerase β

Abstract

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