Mapping abnormal subcortical brain morphometry in an elderly HIV+ cohort

Benjamin S C Wade, Victor G. Valcour, Lauren Wendelken-Riegelhaupt, Pardis Esmaeili-Firidouni, Shantanu H. Joshi, Yalin Wang, Paul M. Thompson

Research output: Chapter in Book/Report/Conference proceedingConference contribution

4 Scopus citations


Over 50% of HIV+ individuals exhibit neurocognitive impairment and subcortical atrophy, but the pattern of brain abnormalities associated with HIV is still poorly understood. Using parametric surface-based shape analyses, we mapped the 3D profile of subcortical morphometry in 63 HIV+ participants and 31 uninfected controls. The thalamus, corpus striatum, hippocampus, amygdala, brainstem, callosum and ventricles were segmented from brain MRIs. To investigate subcortical shape, we analyzed the Jacobian determinant (JD) and radial distances (RD) for structure surfaces. We also investigated effects of nadir CD4+ T-cell counts, viral load, and illness duration on subcortical morphology. Our results characterize subcortical morphometry in older HIV+ people, where participants showed significant volumetric enlargements in the thalamus, left pallidum and the ventricles while showing a reduction in the callosum. Further, RD maps revealed atrophy of the left thalamus and expansion of the brainstem in HIV. RD and JD maps of the right pallidum identified tissue expansion associated with illness duration while the left pallidum showed anterior atrophy and posterior expansion associated with viral load.

Original languageEnglish (US)
Title of host publication2015 IEEE 12th International Symposium on Biomedical Imaging, ISBI 2015
PublisherIEEE Computer Society
Number of pages5
ISBN (Electronic)9781479923748
StatePublished - Jul 21 2015
Event12th IEEE International Symposium on Biomedical Imaging, ISBI 2015 - Brooklyn, United States
Duration: Apr 16 2015Apr 19 2015

Publication series

NameProceedings - International Symposium on Biomedical Imaging
ISSN (Print)1945-7928
ISSN (Electronic)1945-8452


Other12th IEEE International Symposium on Biomedical Imaging, ISBI 2015
Country/TerritoryUnited States


  • HIV
  • MRI
  • classification
  • random forest
  • regularization
  • shape analysis
  • subcortical

ASJC Scopus subject areas

  • Biomedical Engineering
  • Radiology Nuclear Medicine and imaging


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