Lysine-Capped Silica Nanoparticles: A Solid-State NMR Spectroscopy Study

Chengchen Guo, Gregory P. Holland, Jeffery Yarger

Research output: Contribution to journalArticlepeer-review

8 Scopus citations


To achieve the goal of biocompatibility in nano-based materials we must first obtain a fundamental understanding of the physical and chemical behavior of biomolecules at the interfaces of nanomaterials. A first step towards understanding protein interactions with nanomaterials is to understand how individual amino acids interact at the interfaces. In this paper, we investigated the lysine adsorption behavior on fumed silica nanoparticles by solid-state NMR spectroscopy. We use 1H, 13C and 15N solid-state magic angle spinning (MAS) NMR techniques to elucidate how lysine is adsorbed on silica nanoparticles surfaces via strong hydrogen-bonding interaction between the protonated side-chain amine group and silanol group on silica nanoparticles surfaces.∗

Original languageEnglish (US)
Pages (from-to)2261-2266
Number of pages6
JournalMRS Advances
Issue number31
StatePublished - 2016


  • adsorption
  • nanostructure
  • nuclear magnetic resonance (NMR)

ASJC Scopus subject areas

  • Condensed Matter Physics
  • Mechanics of Materials
  • Mechanical Engineering
  • General Materials Science


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