@article{aa2d2fc335d5486fb98253d475e0ccab,
title = "Longitudinal Multi-omics Analyses Identify Responses of Megakaryocytes, Erythroid Cells, and Plasmablasts as Hallmarks of Severe COVID-19",
abstract = "Bernardes et al. explore COVID-19 disease trajectories by performing longitudinal multi-omics analyses in peripheral blood samples from hospitalized patients. The analyses identify increased numbers of plasmablasts, interferon-activated megakaryocytes, and erythroid cells as hallmarks of severe disease and define molecular signatures linked to a fatal COVID-19 disease outcome.",
keywords = "COVID-19, RNA-seq, acute respiratory distress, blood, disease trajectory, immune response, infectious disease, methylation, scRNA-seq, virus",
author = "{HCA Lung Biological Network} and {the Deutsche COVID-19 Omics Initiative (DeCOI)} and Bernardes, {Joana P.} and Neha Mishra and Florian Tran and Thomas Bahmer and Lena Best and Blase, {Johanna I.} and Dora Bordoni and Jeanette Franzenburg and Ulf Geisen and Jonathan Josephs-Spaulding and Philipp K{\"o}hler and Axel K{\"u}nstner and Elisa Rosati and Aschenbrenner, {Anna C.} and Petra Bacher and Nathan Baran and Teide Boysen and Burkhard Brandt and Niklas Bruse and Jonathan D{\"o}rr and Andreas Dr{\"a}ger and Gunnar Elke and David Ellinghaus and Julia Fischer and Michael Forster and Andre Franke and S{\"o}ren Franzenburg and Norbert Frey and Anette Friedrichs and Janina Fu{\ss} and Andreas Gl{\"u}ck and Jacob Hamm and Finn Hinrichsen and Hoeppner, {Marc P.} and Simon Imm and Ralf Junker and Sina Kaiser and Kan, {Ying H.} and Rainer Knoll and Christoph Lange and Georg Laue and Clemens Lier and Matthias Lindner and Georgios Marinos and Robert Markewitz and Jacob Nattermann and Rainer Noth and Peter Pickkers and Rabe, {Klaus F.} and Douglas Shepherd",
note = "Publisher Copyright: {\textcopyright} 2020 Elsevier Inc.",
year = "2020",
month = dec,
day = "15",
doi = "10.1016/j.immuni.2020.11.017",
language = "English (US)",
volume = "53",
pages = "1296--1314.e9",
journal = "Immunity",
issn = "1074-7613",
publisher = "Cell Press",
number = "6",
}