Light-Driven CO2 Reduction by Co-Cytochrome b 562

Rafael Alcala-Torano, Nicholas Halloran, Noah Gwerder, Dayn J. Sommer, Giovanna Ghirlanda

Research output: Contribution to journalArticlepeer-review

7 Scopus citations


The current trend in atmospheric carbon dioxide concentrations is causing increasing concerns for its environmental impacts, and spurring the developments of sustainable methods to reduce CO2 to usable molecules. We report the light-driven CO2 reduction in water in mild conditions by artificial protein catalysts based on cytochrome b562 and incorporating cobalt protoporphyrin IX as cofactor. Incorporation into the protein scaffolds enhances the intrinsic reactivity of the cobalt porphyrin toward proton reduction and CO generation. Mutations around the binding site modulate the activity of the enzyme, pointing to the possibility of further improving catalytic activity through rational design or directed evolution.

Original languageEnglish (US)
Article number609654
JournalFrontiers in Molecular Biosciences
StatePublished - Apr 15 2021


  • CO reduction
  • Carbon fixation
  • catalysis
  • cobalt porphyrin
  • protein design
  • proton reduction

ASJC Scopus subject areas

  • Biochemistry
  • Biochemistry, Genetics and Molecular Biology (miscellaneous)
  • Molecular Biology


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