TY - JOUR
T1 - Light-Activated Tissue-Integrating Sutures as Surgical Nanodevices
AU - Ghosh, Deepanjan
AU - Urie, Russell
AU - Chang, Andy
AU - Nitiyanandan, Rajeshwar
AU - Lee, Jung Keun
AU - Kilbourne, Jacquelyn
AU - Rege, Kaushal
N1 - Publisher Copyright:
© 2019 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
PY - 2019/7/25
Y1 - 2019/7/25
N2 - Sutures are typically the primary means of soft tissue repair in surgery and trauma. Despite their widespread use, sutures do not result in immediate sealing of approximated tissues, which can result in bacterial infection and leakage. Nonabsorbable sutures and staples can be traumatic to tissue, and the trauma can be exacerbated by their subsequent removal. Use of cyanoacrylate glues is limited because of their brittleness and toxicity. In this work, laser-activated tissue-integrating sutures (LATIS) are described as novel nanodevices for soft tissue approximation and repair. Incorporation of gold nanorods within fibers generated from collagen result in LATIS fibers which demonstrate robust photothermal responses following irradiation with near infrared laser light. Compared to conventional sutures, LATIS fibers result in greater biomechanical recovery of incised skin in a mouse model of skin closure after spine surgeries. Histopathology analyses show improved repair of the epidermal gap in skin, which indicate faster tissue recovery using LATIS. The studies indicate that LATIS-facilitated approximation of skin in live mice synergizes the benefits of conventional suturing and laser-activated tissue integration, resulting in new approaches for faster sealing, tissue repair, and healing.
AB - Sutures are typically the primary means of soft tissue repair in surgery and trauma. Despite their widespread use, sutures do not result in immediate sealing of approximated tissues, which can result in bacterial infection and leakage. Nonabsorbable sutures and staples can be traumatic to tissue, and the trauma can be exacerbated by their subsequent removal. Use of cyanoacrylate glues is limited because of their brittleness and toxicity. In this work, laser-activated tissue-integrating sutures (LATIS) are described as novel nanodevices for soft tissue approximation and repair. Incorporation of gold nanorods within fibers generated from collagen result in LATIS fibers which demonstrate robust photothermal responses following irradiation with near infrared laser light. Compared to conventional sutures, LATIS fibers result in greater biomechanical recovery of incised skin in a mouse model of skin closure after spine surgeries. Histopathology analyses show improved repair of the epidermal gap in skin, which indicate faster tissue recovery using LATIS. The studies indicate that LATIS-facilitated approximation of skin in live mice synergizes the benefits of conventional suturing and laser-activated tissue integration, resulting in new approaches for faster sealing, tissue repair, and healing.
KW - gold nanorods
KW - nanodevice
KW - photothermal
KW - skin
KW - trauma
KW - wound healing
UR - http://www.scopus.com/inward/record.url?scp=85065917759&partnerID=8YFLogxK
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U2 - 10.1002/adhm.201900084
DO - 10.1002/adhm.201900084
M3 - Article
C2 - 31066511
AN - SCOPUS:85065917759
SN - 2192-2640
VL - 8
JO - Advanced Healthcare Materials
JF - Advanced Healthcare Materials
IS - 14
M1 - 1900084
ER -