TY - GEN
T1 - Learning brain connectivity of Alzheimer's disease from neuroimaging data
AU - Huang, Shuai
AU - Li, Jing
AU - Sun, Liang
AU - Liu, Jun
AU - Wu, Teresa
AU - Chen, Kewei
AU - Fleisher, Adam
AU - Reiman, Eric
AU - Ye, Jieping
PY - 2009
Y1 - 2009
N2 - Recent advances in neuroimaging techniques provide great potentials for effective diagnosis of Alzheimer's disease (AD), the most common form of dementia. Previous studies have shown that AD is closely related to the alternation in the functional brain network, i.e., the functional connectivity among different brain regions. In this paper, we consider the problem of learning functional brain connectivity from neuroimaging, which holds great promise for identifying image-based markers used to distinguish Normal Controls (NC), patients with Mild Cognitive Impairment (MCI), and patients with AD. More specifically, we study sparse inverse covariance estimation (SICE), also known as exploratory Gaussian graphical models, for brain connectivity modeling. In particular, we apply SICE to learn and analyze functional brain connectivity patterns from different subject groups, based on a key property of SICE, called the "monotone property" we established in this paper. Our experimental results on neuroimaging PET data of 42 AD, 116 MCI, and 67 NC subjects reveal several interesting connectivity patterns consistent with literature findings, and also some new patterns that can help the knowledge discovery of AD.
AB - Recent advances in neuroimaging techniques provide great potentials for effective diagnosis of Alzheimer's disease (AD), the most common form of dementia. Previous studies have shown that AD is closely related to the alternation in the functional brain network, i.e., the functional connectivity among different brain regions. In this paper, we consider the problem of learning functional brain connectivity from neuroimaging, which holds great promise for identifying image-based markers used to distinguish Normal Controls (NC), patients with Mild Cognitive Impairment (MCI), and patients with AD. More specifically, we study sparse inverse covariance estimation (SICE), also known as exploratory Gaussian graphical models, for brain connectivity modeling. In particular, we apply SICE to learn and analyze functional brain connectivity patterns from different subject groups, based on a key property of SICE, called the "monotone property" we established in this paper. Our experimental results on neuroimaging PET data of 42 AD, 116 MCI, and 67 NC subjects reveal several interesting connectivity patterns consistent with literature findings, and also some new patterns that can help the knowledge discovery of AD.
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M3 - Conference contribution
AN - SCOPUS:84863338185
SN - 9781615679119
T3 - Advances in Neural Information Processing Systems 22 - Proceedings of the 2009 Conference
SP - 808
EP - 816
BT - Advances in Neural Information Processing Systems 22 - Proceedings of the 2009 Conference
PB - Neural Information Processing Systems
T2 - 23rd Annual Conference on Neural Information Processing Systems, NIPS 2009
Y2 - 7 December 2009 through 10 December 2009
ER -