Abstract
A new cell growth inhibitory (PS ED502.2 μg/mL) phenanthraquinone designated combretastatin C-l (2) has been isolated from the African tree Combretum caffrum. The structure (2) assigned combretastatin C-l was based on high-resolution mass and NMR spectral analyses and confirmed by total syntheses. Synthetic routes 5b → 6b → 2 and especially 5c → 6c → 2 proved to be quite practical.
Original language | English (US) |
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Pages (from-to) | 4105-4114 |
Number of pages | 10 |
Journal | Journal of Organic Chemistry |
Volume | 54 |
Issue number | 17 |
DOIs | |
State | Published - Aug 1 1989 |
ASJC Scopus subject areas
- Organic Chemistry