Isolation, Structure, and Synthesis of Combretastatin C-l

Sheo Bux Singh, George Pettit

Research output: Contribution to journalArticlepeer-review

40 Scopus citations


A new cell growth inhibitory (PS ED502.2 μg/mL) phenanthraquinone designated combretastatin C-l (2) has been isolated from the African tree Combretum caffrum. The structure (2) assigned combretastatin C-l was based on high-resolution mass and NMR spectral analyses and confirmed by total syntheses. Synthetic routes 5b → 6b → 2 and especially 5c → 6c → 2 proved to be quite practical.

Original languageEnglish (US)
Pages (from-to)4105-4114
Number of pages10
JournalJournal of Organic Chemistry
Issue number17
StatePublished - Aug 1 1989

ASJC Scopus subject areas

  • Organic Chemistry


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