Isolation of geodiastatins 1 and 2 from the marine sponge geodia mesotriaena

George Pettit, John A. Rideout, Julia A. Hasler

Research output: Contribution to journalArticlepeer-review

18 Scopus citations


An aqueous extract of the Gulf of California Geodia mesotriaena von Lendenfeld (Porifera) has been found to contain two chromoprotein antineoplastic agents designated geodiastatins 1 and 2. The active brownish-black proteins from this siliceous sponge were found to contain major (>1%) amounts of silicon and to inhibit growth of the murine P388 lymphocytic leukemia. A related protein (geodiatoxin 1) was found to be toxic at 6 mg/kg (LD100, mouse).

Original languageEnglish (US)
Pages (from-to)588-592
Number of pages5
JournalJournal of Natural Products
Issue number5
StatePublished - Sep 1981

ASJC Scopus subject areas

  • Analytical Chemistry
  • Molecular Medicine
  • Pharmacology
  • Pharmaceutical Science
  • Drug Discovery
  • Complementary and alternative medicine
  • Organic Chemistry


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