Isolation and structure of the human cancer cell growth inhibitory cyclodepsipeptide dolastatin 16

George Pettit; Jun-Ping Xu; Fiona Hogan; Michael D. Williams; Dennis L. Doubek; Jean M. Schmidt; Ronald L. Cerny; Michael R. Boyd

doi:10.1021/np9700230

Isolation and structure of the human cancer cell growth inhibitory cyclodepsipeptide dolastatin 16

George Pettit, Jun-Ping Xu, Fiona Hogan, Michael D. Williams, Dennis L. Doubek, Jean M. Schmidt, Ronald L. Cerny, Michael R. Boyd

Molecular Sciences, School of (SMS)

Research output: Contribution to journal › Article › peer-review

60 Scopus citations

Abstract

An investigation of the sea hare Dolabella auricularia from Papua New Guinea has led to discovery of the new cyclodepsipeptide dolastatin 16 (3) containing two new amino acid units designated dolamethylleuine (Dml) and dolaphenvaline (Dpv). The structural elucidation was achieved by means of high-field (500 MHz) NMR and tandem MS/MS mass spectral interpretations and allowed the assignment cyclo-(Pro-Dpv-Pro-Dml-O-Lac-Pro-O-Hiv-MeVal). The new depsipeptide exhibited strong inhibition of growth against a variety of human cancer cell lines.

Original language	English (US)
Pages (from-to)	752-754
Number of pages	3
Journal	Journal of Natural Products
Volume	60
Issue number	8
DOIs	https://doi.org/10.1021/np9700230
State	Published - Aug 1997

ASJC Scopus subject areas

Analytical Chemistry
Molecular Medicine
Pharmacology
Pharmaceutical Science
Drug Discovery
Complementary and alternative medicine
Organic Chemistry

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title = "Isolation and structure of the human cancer cell growth inhibitory cyclodepsipeptide dolastatin 16",

abstract = "An investigation of the sea hare Dolabella auricularia from Papua New Guinea has led to discovery of the new cyclodepsipeptide dolastatin 16 (3) containing two new amino acid units designated dolamethylleuine (Dml) and dolaphenvaline (Dpv). The structural elucidation was achieved by means of high-field (500 MHz) NMR and tandem MS/MS mass spectral interpretations and allowed the assignment cyclo-(Pro-Dpv-Pro-Dml-O-Lac-Pro-O-Hiv-MeVal). The new depsipeptide exhibited strong inhibition of growth against a variety of human cancer cell lines.",

author = "George Pettit and Jun-Ping Xu and Fiona Hogan and Williams, {Michael D.} and Doubek, {Dennis L.} and Schmidt, {Jean M.} and Cerny, {Ronald L.} and Boyd, {Michael R.}",

year = "1997",

month = aug,

doi = "10.1021/np9700230",

language = "English (US)",

volume = "60",

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T1 - Isolation and structure of the human cancer cell growth inhibitory cyclodepsipeptide dolastatin 16

AU - Pettit, George

AU - Xu, Jun-Ping

AU - Hogan, Fiona

AU - Williams, Michael D.

AU - Doubek, Dennis L.

AU - Schmidt, Jean M.

AU - Cerny, Ronald L.

AU - Boyd, Michael R.

PY - 1997/8

Y1 - 1997/8

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AB - An investigation of the sea hare Dolabella auricularia from Papua New Guinea has led to discovery of the new cyclodepsipeptide dolastatin 16 (3) containing two new amino acid units designated dolamethylleuine (Dml) and dolaphenvaline (Dpv). The structural elucidation was achieved by means of high-field (500 MHz) NMR and tandem MS/MS mass spectral interpretations and allowed the assignment cyclo-(Pro-Dpv-Pro-Dml-O-Lac-Pro-O-Hiv-MeVal). The new depsipeptide exhibited strong inhibition of growth against a variety of human cancer cell lines.

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JO - Journal of Natural Products

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Isolation and structure of the human cancer cell growth inhibitory cyclodepsipeptide dolastatin 16

Abstract

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