TY - JOUR
T1 - Isolation and structure of the human cancer cell growth inhibitory cyclic decapeptides phakellistatins 7, 8 and 91,2
AU - Pettit, George
AU - Xu, Jun-Ping
AU - Dorsaz, Ann Christine
AU - Williams, Michael D.
AU - Boyd, Michael R.
AU - Cerny, Ronald L.
N1 - Funding Information:
TackettM, s. DeniseN ielsen-Tacketatn, dM r. Lee Williams. The four sectort andemm asss pectrometwera s purchasewdi thf undsa wardedb y the formerN SF regionailn strumentatiopnr ogram(g rantC HE-8620177a)n d the Universityo f Nebraska-Lincoln.A dditionals upportw as providedb y the NSF BiologyD ivision(grant DIR-9017262)
PY - 1995/7/6
Y1 - 1995/7/6
N2 - Phakellistatins 7-9 respresent the first cancer cell growth inhibitory (P388 ED50 3.0, 2.9 and 4.1 μg/mL respectively) cyclic decapeptides. Each was isolated from the Federated States of Micronesia (Chuuk) marine sponge Phakellia costata. The Federated States of Micronesia (Chuuk) marine sponge Phakellia costata has been found to contain (10-5 and 10-6% yields) three cancer cell line active (P388 ED50 3.0, 2.9 and 4.1 μg/mL respectively) cyclic decapeptides named phakellistatins 7 (1), 8 (2) and 9 (3). Phakellistatins 7-9 represent the first cancer cell growth inhibitory cyclic decapeptides isolated from a marine sponge.
AB - Phakellistatins 7-9 respresent the first cancer cell growth inhibitory (P388 ED50 3.0, 2.9 and 4.1 μg/mL respectively) cyclic decapeptides. Each was isolated from the Federated States of Micronesia (Chuuk) marine sponge Phakellia costata. The Federated States of Micronesia (Chuuk) marine sponge Phakellia costata has been found to contain (10-5 and 10-6% yields) three cancer cell line active (P388 ED50 3.0, 2.9 and 4.1 μg/mL respectively) cyclic decapeptides named phakellistatins 7 (1), 8 (2) and 9 (3). Phakellistatins 7-9 represent the first cancer cell growth inhibitory cyclic decapeptides isolated from a marine sponge.
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U2 - 10.1016/0960-894X(95)00219-J
DO - 10.1016/0960-894X(95)00219-J
M3 - Article
AN - SCOPUS:0029032630
SN - 0960-894X
VL - 5
SP - 1339
EP - 1344
JO - Bioorganic and Medicinal Chemistry Letters
JF - Bioorganic and Medicinal Chemistry Letters
IS - 13
ER -