Isolation and Structure of Spongistatin 1

George Pettit, Zbigniew Cichacz, Feng Gao, Cherry L. Herald, Michael R. Boyd, Jean M. Schmidt, John N A Hooper

Research output: Contribution to journalArticlepeer-review

326 Scopus citations


An Eastern Indian Ocean sponge in the genus Spongia contains a structurally unprecedented macrocyclic lactone, spongistatin 1 (3), with extremely potent activity against selected human tumor cell types in the U.S. National Cancer Institute's primary screen.

Original languageEnglish (US)
Pages (from-to)1302-1304
Number of pages3
JournalJournal of Organic Chemistry
Issue number6
StatePublished - 1993

ASJC Scopus subject areas

  • Organic Chemistry


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