Isolation and structure of bryostatins 14 and 15

George Pettit, F. Gao, D. Sengupta, J. C. Coll., C. L. Herald, D. L. Doubek, J. M. Schmidt, J. R. van Camp, J. J. Rudloe, R. A. Nieman

Research output: Contribution to journalArticlepeer-review

49 Scopus citations


Further investigation of constituents from the marine bryozoan Bugula neritina employing new 1,000 kg recollections from the Gulf of Mexico and Eastern Pacific Ocean (California) has led to isolation and structural determination of two previously undetected members of the bryostatin (1-13) series, bryostatins 14 (14) and 15 (15). Structural analyses were conducted primarily with high field (400 MHz) NMR and high resolution mass spectral techniques. Both new bryostatins significantly inhibited growth of the P388 lymphocytic leukemia.

Original languageEnglish (US)
Pages (from-to)3601-3610
Number of pages10
Issue number22
StatePublished - 1991

ASJC Scopus subject areas

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry


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