Isolation and characterization of antibody fragments selective for human FTD brain derived TDP-43 variants

Keyphrases

• TAR DNA-binding Protein 43 (TDP-43) 100%
• Frontotemporal Dementia 100%
• Antibody Fragment 100%
• Brain-inspired 100%
• ScFv 27%
• Serum Samples 16%
• Tyrosyl-DNA Phosphodiesterase 1 (TDP1) 16%
• Age-matched 16%
• Brain Tissue 11%
• Tissue Sampling 11%
• Disease-specific 11%
• Alzheimer's Disease 5%
• Neuronal Cells 5%
• Postmortem Tissue 5%
• Disease Progression 5%
• Diagnostic Tool 5%
• Early-onset Dementia 5%
• Atomic Force Microscopy 5%
• Biopanning 5%
• Potential Therapeutics 5%
• Cognitively Normal 5%
• Immunohistochemical Analysis 5%
• Therapeutic Tool 5%
• Atrophy 5%
• C-terminal Fragments 5%
• Dementia Diseases 5%
• Brain Tissue Samples 5%
• Phage Display Library 5%
• Brain Slice 5%
• Therapeutic Implications 5%
• Single-chain Variable Fragment 5%
• Temporal Region 5%
• Frontal Region 5%
• Tissue Slices 5%
• Alzheime's Disease 5%
• Transcription-translation (TX-TL) 5%
• Induced Toxicity 5%
• Language Behavior 5%

Biochemistry, Genetics and Molecular Biology

• DNA-binding Protein 100%
• TDP1 50%
• Transcription 25%
• C-Terminus 25%
• Atomic Force Microscopy 25%
• Phage Display 25%
• Biopanning 25%
• Single-Chain Variable Fragment 25%
• Staining 25%
• Brain Slice 25%

Neuroscience

• DNA-binding Protein 100%
• Frontotemporal Dementia 100%
• Behavior (Neuroscience) 5%
• Alzheimer's Disease 5%
• Amyotrophic Lateral Sclerosis 5%
• Single-Chain Variable Fragment 5%
• Brain Slice 5%
• Staining Technique 5%
• C-Terminus 5%
• Nucleus 5%
• Biological Marker 5%