Investigating Tissue Regeneration Using the DUAL Control Genetic Ablation System

Research output: Chapter in Book/Report/Conference proceedingChapter


Genetic ablation is a highly efficient method to study regeneration in vivo by stimulating tissue-specific cell death that subsequently induces regrowth and repair in a developing organism. This approach has been particularly successful in Drosophila, for which various temperature-based genetic ablation tools have been developed to explore the complexities of regeneration in larval imaginal discs. Here, we describe the use of a recently established ablation system called DUAL Control, which can be used to both characterize the damage response and genetically manipulate blastema cells to identify novel regulators of regeneration.

Original languageEnglish (US)
Title of host publicationMethods in Molecular Biology
PublisherHumana Press Inc.
Number of pages16
StatePublished - 2023

Publication series

NameMethods in Molecular Biology
ISSN (Print)1064-3745
ISSN (Electronic)1940-6029


  • Drosophila
  • Gene regulation
  • Genetics
  • Repair
  • Screening
  • Tissue regeneration
  • Wound healing

ASJC Scopus subject areas

  • Molecular Biology
  • Genetics


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