@article{9c4973124482432db496ce42d682b2c2,
title = "Interrupting sitting time in postmenopausal women: Protocol for the rise for health randomized controlled trial",
abstract = "Background: Many older adults spend the majority of their waking hours sitting, which increases their risk of chronic diseases. Given the challenges that many older adults face when engaging in moderate-to-vigorous physical activity, understanding the health benefits of decreasing sitting time and increasing the number of sit-to-stand transitions is needed to address this growing public health concern. Objective: The aim of this 3-arm randomized controlled trial is to investigate how changes in sitting time and brief sit-to-stand transitions impact biomarkers of healthy aging and physical, emotional, and cognitive functioning compared with a healthy attention control arm. Methods: Sedentary and postmenopausal women (N=405) will be recruited and randomly assigned to 1 of the 3 study conditions for 3 months: healthy living attention control (Healthy Living), reduce sitting time (Reduce Sitting), and increase sit-to-stand transitions (Increase Transitions). Assessments conducted at baseline and 3 months included fasting blood draw, blood pressure, anthropometric measurements, physical functioning, cognitive testing, and 7 days of a thigh-worn accelerometer (activPAL) and a hip-worn accelerometer (ActiGraph). Blood-based biomarkers of healthy aging included those associated with glycemic control (glycated hemoglobin, fasting plasma insulin and glucose, and homeostatic model assessment of insulin resistance). Results: Recruitment began in May 2018. The intervention is ongoing, with data collection expected to continue through the end of 2022. Conclusions: The Rise for Health study is designed to test whether 2 different approaches to interrupting sitting time can improve healthy aging in postmenopausal women. Results from this study may inform the development of sedentary behavior guidelines and interventions to reduce sitting time in older adults.",
keywords = "Biomarkers, Cardiometabolic health, Cognitive function, Older adults, Physical function, Sedentary behavior",
author = "Hartman, {Sheri J.} and Dillon, {Lindsay W.} and LaCroix, {Andrea Z.} and Loki Natarajan and Sears, {Dorothy D.} and Neville Owen and Dunstan, {David W.} and Sallis, {James F.} and Simon Schenk and Matthew Allison and Michelle Takemoto and Herweck, {Alexandra M.} and Bao Nguyen and Rosenberg, {Dori E.}",
note = "Funding Information: Rise for Health is a 3-arm RCT of 2 interventions that address changing sitting in overweight, postmenopausal women over a 3-month period, compared with an attention control condition. This study is one of the three projects within the National Institute on Aging Program Grant named Sedentary Time and Aging Mortality and Physical Function (STAR). The program grant proposes a paradigm shift away from energy expenditure as the primary mechanism for improving health outcomes to investigate potentially feasible behaviors such as brief sit-to-stand transitions that expend little energy but engage muscles, improve postural blood flow, and may impact physical functioning in older adults. The STAR program includes 3 projects and 2 cores for studying postmenopausal women at risk of chronic diseases. In addition to the RCT described here (project 2), STAR includes a 3-condition randomized crossover laboratory trial of strategies to interrupt sitting time (n=78; project 1) and a study that optimizes new computational techniques for objectively measuring sedentary behavior to apply to existing prospective hip-worn accelerometer data from the Objective Physical Activity and Cardiovascular Disease Health in Older Women (OPACH) cohort of the Women Health Initiative (N>6000, project 3). All projects are investigating the consequences of sitting and brief sit-to-stand transitions on the mechanisms of healthy aging, including glucose regulation and endothelial functioning. The STAR program will provide a comprehensive evidence base that can inform public health guidelines on sitting behaviors and healthy aging. Funding Information: This work was supported by the National Institute of Aging (grant P01 AG052352). Coauthors (NO and DD) were supported a National Health and Medical Research Council (NHMRC) of Australia Centre of Research Excellence grant (#1057608), the Victorian Government Operational Infrastructure scheme, and the NHMRC Fellowships scheme. Publisher Copyright: {\textcopyright} Sheri J Hartman, Lindsay W Dillon, Andrea Z LaCroix, Loki Natarajan, Dorothy D Sears, Neville Owen, David W Dunstan, James F Sallis, Simon Schenk, Matthew Allison, Michelle Takemoto, Alexandra M Herweck, Bao Nguyen, Dori E Rosenberg.",
year = "2021",
month = may,
doi = "10.2196/28684",
language = "English (US)",
volume = "10",
journal = "JMIR Research Protocols",
issn = "1929-0748",
publisher = "JMIR Publications Inc.",
number = "5",
}