Integration of 3D1H-magnetic resonance spectroscopy data into neuronavigation systems for tumor biopsies

Berkay Kanberoglu, Nina Z. Moore, David Frakes, Lina Karam, Josef P. Debbins, Mark C. Preul

Research output: Chapter in Book/Report/Conference proceedingConference contribution


Many important applications in clinical medicine can benefit from the fusion of spectroscopy data with anatomical images. For example, the correlation of metabolite profiles with specific regions of interest in anatomical tumor images can be useful in characterizing and treating heterogeneous tumors that appear structurally homogeneous. Such applications can build on the correlation of data from in-vivo Proton Magnetic Resonance Spectroscopy Imaging ( 1H-MRSI) with data from genetic and ex-vivo Nuclear Magnetic Resonance spectroscopy. To establish that correlation, tissue samples must be neurosurgically extracted from specifically identified locations with high accuracy. Toward that end, this paper presents new neuronavigation technology that enhances current clinical capabilities in the context of neurosurgical planning and execution. The proposed methods improve upon the current state-of-the-art in neuronavigation through the use of detailed three dimensional (3D) 1H-MRSI data. MRSI spectra are processed and analyzed, and specific voxels are selected based on their chemical contents. 3D neuronavigation overlays are then generated and applied to anatomical image data in the operating room. Without such technology, neurosurgeons must rely on memory and other qualitative resources alone for guidance in accessing specific MRSI-identified voxels. In contrast, MRSI-based overlays provide quantitative visual cues and location information during neurosurgery. The proposed methods enable a progressive new form of online MRSI-guided neuronavigation that we demonstrate in this study through phantom validation and clinical application.

Original languageEnglish (US)
Title of host publicationMedical Imaging 2013
Subtitle of host publicationImage-Guided Procedures, Robotic Interventions, and Modeling
StatePublished - 2013
EventMedical Imaging 2013: Image-Guided Procedures, Robotic Interventions, and Modeling - Lake Buena Vista, FL, United States
Duration: Feb 12 2013Feb 14 2013

Publication series

NameProceedings of SPIE - The International Society for Optical Engineering
ISSN (Print)0277-786X


OtherMedical Imaging 2013: Image-Guided Procedures, Robotic Interventions, and Modeling
Country/TerritoryUnited States
CityLake Buena Vista, FL


  • Biopsy
  • Image guided surgery
  • MRS
  • Magnetic resonance spectroscopy
  • Meningioma
  • Neuronavigation

ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials
  • Condensed Matter Physics
  • Computer Science Applications
  • Applied Mathematics
  • Electrical and Electronic Engineering


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