@inproceedings{c619e76dcb814ffda42858b1ea806e6c,
title = "Integrated platform for ion channel sensing",
abstract = "Conductance measurement of single ion channels and related stochastic signals is a promising technique for the development of a functional biosensor. We present results showing that silicon substrates can be used as a low noise, universal platform for recording the electrical activity of single ion channels inserted into bilayer membranes. Bilayers were suspended on polytetrafluoroethylene coated, 150μm apertures etched into silicon substrates and then oxidized with common silicon processing techniques. The overall noise of the system was reduced with a 75μm thick SU-8 layer and integrated silver/silver chloride electrodes. Phase sensitive detection of single OmpF porin ion channels using the silicon device and a lock-in amplifier were made and demonstrate the system's capability as a sensor in high noise environments.",
author = "Wilk, {S. J.} and L. Petrossian and Michael Goryll and Trevor Thornton and Stephen Goodnick and Tang, {J. M.} and Eisenberg, {R. S.}",
year = "2005",
doi = "10.1109/ICSENS.2005.1597912",
language = "English (US)",
isbn = "0780390563",
series = "Proceedings of IEEE Sensors",
pages = "1165--1168",
booktitle = "Proceedings of the Fourth IEEE Conference on Sensors 2005",
note = "Fourth IEEE Conference on Sensors 2005 ; Conference date: 31-10-2005 Through 03-11-2005",
}