TY - JOUR
T1 - Inorganic nanoparticles for cancer imaging and therapy
AU - Huang, Huang Chiao
AU - Barua, Sutapa
AU - Sharma, Gaurav
AU - Dey, Sandwip
AU - Rege, Kaushal
N1 - Funding Information:
KR and SKD acknowledge financial support from the National Cancer Institute, National Institutes of Health ( 5R21CA133618-02 ) and the National Science Foundation ( CBET-0829128 ). GS acknowledges financial support from the California Breast Cancer Research Program , Grant # 14FB-0107 .
PY - 2011/11/7
Y1 - 2011/11/7
N2 - Inorganic nanoparticles have received increased attention in the recent past as potential diagnostic and therapeutic systems in the field of oncology. Inorganic nanoparticles have demonstrated successes in imaging and treatment of tumors both ex vivo and in vivo, with some promise towards clinical trials. This review primarily discusses progress in applications of inorganic nanoparticles for cancer imaging and treatment, with an emphasis on in vivo studies. Advances in the use of semiconductor fluorescent quantum dots, carbon nanotubes, gold nanoparticles (spheres, shells, rods, cages), iron oxide magnetic nanoparticles and ceramic nanoparticles in tumor targeting, imaging, photothermal therapy and drug delivery applications are discussed. Limitations and toxicity issues associated with inorganic nanoparticles in living organisms are also discussed.
AB - Inorganic nanoparticles have received increased attention in the recent past as potential diagnostic and therapeutic systems in the field of oncology. Inorganic nanoparticles have demonstrated successes in imaging and treatment of tumors both ex vivo and in vivo, with some promise towards clinical trials. This review primarily discusses progress in applications of inorganic nanoparticles for cancer imaging and treatment, with an emphasis on in vivo studies. Advances in the use of semiconductor fluorescent quantum dots, carbon nanotubes, gold nanoparticles (spheres, shells, rods, cages), iron oxide magnetic nanoparticles and ceramic nanoparticles in tumor targeting, imaging, photothermal therapy and drug delivery applications are discussed. Limitations and toxicity issues associated with inorganic nanoparticles in living organisms are also discussed.
KW - Carbon nanotubes
KW - Ceramic nanoparticles
KW - Gold nanoparticles
KW - Magnetic nanoparticles
KW - Quantum dots
KW - Theranostics
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U2 - 10.1016/j.jconrel.2011.06.004
DO - 10.1016/j.jconrel.2011.06.004
M3 - Review article
C2 - 21723891
AN - SCOPUS:80054689368
SN - 0168-3659
VL - 155
SP - 344
EP - 357
JO - Journal of Controlled Release
JF - Journal of Controlled Release
IS - 3
ER -