TY - JOUR
T1 - Injury response checkpoint and developmental timing in insects
AU - Hackney Price, Jennifer
AU - Cherbas, Peter
N1 - Publisher Copyright:
© 2014 Taylor & Francis Group, LLC.
PY - 2014/1/1
Y1 - 2014/1/1
N2 - In insects, localized tissue injury often leads to global (organism-wide) delays in development and retarded metamorphosis. In Drosophila, for example, injuries to the larval imaginal discs can retard pupariation and prolong metamorphosis. Injuries induced by treatments such as radiation, mechanical damage and induction of localized cell death can trigger similar delays. In most cases, the duration of the developmental delay appears to be correlated with the extent of damage, but the effect is also sensitive to the developmental stage of the treated animal. The proximate cause of the delays is likely a disruption of the ecdysone signaling pathway, but the intermediate steps leading from tissue injury and/or regeneration to that disruption remain unknown. Here, we review the evidence for injury-induced developmental delays, and for a checkpoint or checkpoints associated with the temporal progression of development and the on-going efforts to define the mechanisms involved.
AB - In insects, localized tissue injury often leads to global (organism-wide) delays in development and retarded metamorphosis. In Drosophila, for example, injuries to the larval imaginal discs can retard pupariation and prolong metamorphosis. Injuries induced by treatments such as radiation, mechanical damage and induction of localized cell death can trigger similar delays. In most cases, the duration of the developmental delay appears to be correlated with the extent of damage, but the effect is also sensitive to the developmental stage of the treated animal. The proximate cause of the delays is likely a disruption of the ecdysone signaling pathway, but the intermediate steps leading from tissue injury and/or regeneration to that disruption remain unknown. Here, we review the evidence for injury-induced developmental delays, and for a checkpoint or checkpoints associated with the temporal progression of development and the on-going efforts to define the mechanisms involved.
KW - Developmental Timing
KW - Drosophila Development
KW - Ecdysone
KW - Injury
KW - PTTH
KW - Regeneration
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U2 - 10.1080/19336934.2015.1034913
DO - 10.1080/19336934.2015.1034913
M3 - Review article
C2 - 25833067
AN - SCOPUS:84945185372
SN - 1933-6934
VL - 8
SP - 226
EP - 231
JO - Fly
JF - Fly
IS - 4
ER -