TY - JOUR
T1 - Immunohistochemical studies of blood group substance h in colorectal tumors using a monoclonal antibody
AU - Compton, Carolyn
AU - Wyatt, Richard
AU - Konugres, Angelyn
AU - Ehrenthal, Deborah
AU - Durda, Paul
PY - 1987/1/1
Y1 - 1987/1/1
N2 - With the use of a murine monoclonal antibody with specificity for human blood group substance H, the distribution of this antigen on colorectal carcinomas and adenomatous polyps has been studied by immunohistochemistry. All of the 20 carcinomas studied were found to express H substance regardless of their location in the colon, their pathologic grade, or their clinical stage. Adenomas were variably positive for H substance, and expression of the antigen appeared to correlate with the degree of dysplasia seen on microscopic examination. Normal colonic mucosa, nonadenomatous polyps, and nonepithelial colonic neoplasms studied failed to express H substance. The results suggest that detection of H substance expression may be useful in the diagnosis of colonic malignancies and dysplastic premalignant lesions. Cancer 59:118–127, 1987.
AB - With the use of a murine monoclonal antibody with specificity for human blood group substance H, the distribution of this antigen on colorectal carcinomas and adenomatous polyps has been studied by immunohistochemistry. All of the 20 carcinomas studied were found to express H substance regardless of their location in the colon, their pathologic grade, or their clinical stage. Adenomas were variably positive for H substance, and expression of the antigen appeared to correlate with the degree of dysplasia seen on microscopic examination. Normal colonic mucosa, nonadenomatous polyps, and nonepithelial colonic neoplasms studied failed to express H substance. The results suggest that detection of H substance expression may be useful in the diagnosis of colonic malignancies and dysplastic premalignant lesions. Cancer 59:118–127, 1987.
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U2 - 10.1002/1097-0142(19870101)59:1<118::AID-CNCR2820590125>3.0.CO;2-K
DO - 10.1002/1097-0142(19870101)59:1<118::AID-CNCR2820590125>3.0.CO;2-K
M3 - Article
C2 - 2431754
AN - SCOPUS:0023121895
SN - 0008-543X
VL - 59
SP - 118
EP - 127
JO - Cancer
JF - Cancer
IS - 1
ER -