Identification of DNA basepairing via tunnel-current decay

Jin He, Lisha Lin, Peiming Zhang, Stuart Lindsay

Research output: Contribution to journalArticlepeer-review

81 Scopus citations


We propose a new approach for reading the sequence of a DNA molecule passing between electrodes on a nanopore, using hydrogen bond- mediated tunneling signals. The base-electrode interaction is modeled using a nucleo-base-functionalized STM probe that is pulled away from a nucleoside monolayer. Watson-Crick recognition results in slow decay of the tunnel current, which is uniquely characteristic of the basepair in over half the reads. Thirteen independent reads would yield the desired 99.99% accuracy.

Original languageEnglish (US)
Pages (from-to)3854-3858
Number of pages5
JournalNano Letters
Issue number12
StatePublished - Dec 2007

ASJC Scopus subject areas

  • Bioengineering
  • General Chemistry
  • General Materials Science
  • Condensed Matter Physics
  • Mechanical Engineering


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