Identification of a bovine coronavirus packaging signal

Raymond Cologna, Brenda G. Hogue

Research output: Contribution to journalArticlepeer-review

35 Scopus citations


A region of the bovine coronavirus (BCV) genome that functions as a packaging signal has been cloned. The 291-nucleotide clone shares 72% homology with the region of mouse hepatitis coronavirus (MHV) gene 1b that contains the packaging signal. RNA transcripts were packaged into both BCV and MHV virions when the cloned region was appended to a noncoronavirus RNA. This is the first identification of a BCV packaging signal. The data demonstrate that the BCV genome contains a sequence that is conserved at both the sequence and functional levels, thus broadening our insight into coronavirus packaging.

Original languageEnglish (US)
Pages (from-to)580-583
Number of pages4
JournalJournal of virology
Issue number1
StatePublished - 2000
Externally publishedYes

ASJC Scopus subject areas

  • Microbiology
  • Immunology
  • Insect Science
  • Virology


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