How poxviruses oppose apoptosis

Grant McFadden, Michele Barry

Research output: Contribution to journalArticlepeer-review

36 Scopus citations


Poxviruses express a variety of proteins that are able to modulate the innate cellular apoptotic response triggered by virus infection. Poxviruses are the only DNA viruses to replicate exclusively in the cytoplasm of infected cells, and to date, members of this family have been shown to encode a wide variety of proteins that block or delay apoptosis, including caspase inhibitors, other serpins, death domain effectors, bcl-2/CED-9 homologs, modulators of the FAS/TNF pathway, and inhibitors of PKR. It is predicted that this list of poxvirus apoptosis modulators will continue to grow in the coming years and should provide an increasingly rich and diverse family of apoptosis regulators.

Original languageEnglish (US)
Pages (from-to)429-442
Number of pages14
JournalSeminars in Virology
Issue number5
StatePublished - Apr 1998
Externally publishedYes


  • Bcl-2 homologs
  • Caspase inhibitors
  • Host range
  • PKR
  • Serpin
  • TNF
  • crmA

ASJC Scopus subject areas

  • Immunology
  • Virology


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