HLA and mate selection: No evidence in South Amerindians

Philip W. Hedrick, Francis L. Black

Research output: Contribution to journalArticlepeer-review

109 Scopus citations


There have been reports of nonrandom mating (negative-assortative mating) or preference for individuals of different major histocompatibility complex (MHC) genotypes in both mice and humans. We have examined the association of HLA-A and HLA-B genotypes, both for each locus by itself and for two-locus genotypes, in mates of 194 couples from 11 South Amerindian tribes. The proportion of couples sampled averaged >50% of the total matings with progeny for 10 of the tribes. In nearly all cases, HLA-sharing proportions were very close to those expected from random mating, suggesting strong negative-assortative mating for MHC is not present in these South Amerindians.

Original languageEnglish (US)
Pages (from-to)505-511
Number of pages7
JournalAmerican Journal of Human Genetics
Issue number3
StatePublished - Sep 1997

ASJC Scopus subject areas

  • Genetics
  • Genetics(clinical)


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