Hematoporphyrin derivative: Quantitative uptake in dimethylhydrazine‐induced murine colorectal carcinoma

M. V. Agrez; R. E. Wharen; R. E. Anderson; E. R. Laws; D. M. Ilstrup; D. A. Cortese; R. G. Shorter; M. M. Lieber

doi:10.1002/jso.2930240305

Hematoporphyrin derivative: Quantitative uptake in dimethylhydrazine‐induced murine colorectal carcinoma

M. V. Agrez, R. E. Wharen, R. E. Anderson, E. R. Laws, D. M. Ilstrup, D. A. Cortese, R. G. Shorter, M. M. Lieber

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25 Scopus citations

Abstract

The selective affinity of hematoporphyrin derivative (HpD) for dimethyl‐hydrazine‐induced colorectal malignancies in mice was evaluated both visually and by a quantitative microfluorescent photometric technique. A significant corelation was found between higher concentrations of HpD in colon biopsies determined by microfluorescence spectroscopy and the presence of carcinoma cells in these biopsies as identified by histologic examination. Visual inspection of the gross fluorescence of tumor‐bearing colons in this experimental model, however, was not helpful in differentiating malignant from nonmalignant tissue. The implications of this study regarding the clinical application of HpD tumor fluorescence for the detection of colorectal carcinoma are discussed.

Original language	English (US)
Pages (from-to)	173-176
Number of pages	4
Journal	Journal of Surgical Oncology
Volume	24
Issue number	3
DOIs	https://doi.org/10.1002/jso.2930240305
State	Published - Nov 1983
Externally published	Yes

Keywords

colorectal carcinoma
hematoporphyrin derivative

ASJC Scopus subject areas

Surgery
Oncology

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10.1002/jso.2930240305

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title = "Hematoporphyrin derivative: Quantitative uptake in dimethylhydrazine‐induced murine colorectal carcinoma",

abstract = "The selective affinity of hematoporphyrin derivative (HpD) for dimethyl‐hydrazine‐induced colorectal malignancies in mice was evaluated both visually and by a quantitative microfluorescent photometric technique. A significant corelation was found between higher concentrations of HpD in colon biopsies determined by microfluorescence spectroscopy and the presence of carcinoma cells in these biopsies as identified by histologic examination. Visual inspection of the gross fluorescence of tumor‐bearing colons in this experimental model, however, was not helpful in differentiating malignant from nonmalignant tissue. The implications of this study regarding the clinical application of HpD tumor fluorescence for the detection of colorectal carcinoma are discussed.",

keywords = "colorectal carcinoma, hematoporphyrin derivative",

author = "Agrez, {M. V.} and Wharen, {R. E.} and Anderson, {R. E.} and Laws, {E. R.} and Ilstrup, {D. M.} and Cortese, {D. A.} and Shorter, {R. G.} and Lieber, {M. M.}",

year = "1983",

month = nov,

doi = "10.1002/jso.2930240305",

language = "English (US)",

volume = "24",

pages = "173--176",

journal = "Journal of Surgical Oncology",

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TY - JOUR

T1 - Hematoporphyrin derivative

T2 - Quantitative uptake in dimethylhydrazine‐induced murine colorectal carcinoma

AU - Agrez, M. V.

AU - Wharen, R. E.

AU - Anderson, R. E.

AU - Laws, E. R.

AU - Ilstrup, D. M.

AU - Cortese, D. A.

AU - Shorter, R. G.

AU - Lieber, M. M.

PY - 1983/11

Y1 - 1983/11

N2 - The selective affinity of hematoporphyrin derivative (HpD) for dimethyl‐hydrazine‐induced colorectal malignancies in mice was evaluated both visually and by a quantitative microfluorescent photometric technique. A significant corelation was found between higher concentrations of HpD in colon biopsies determined by microfluorescence spectroscopy and the presence of carcinoma cells in these biopsies as identified by histologic examination. Visual inspection of the gross fluorescence of tumor‐bearing colons in this experimental model, however, was not helpful in differentiating malignant from nonmalignant tissue. The implications of this study regarding the clinical application of HpD tumor fluorescence for the detection of colorectal carcinoma are discussed.

AB - The selective affinity of hematoporphyrin derivative (HpD) for dimethyl‐hydrazine‐induced colorectal malignancies in mice was evaluated both visually and by a quantitative microfluorescent photometric technique. A significant corelation was found between higher concentrations of HpD in colon biopsies determined by microfluorescence spectroscopy and the presence of carcinoma cells in these biopsies as identified by histologic examination. Visual inspection of the gross fluorescence of tumor‐bearing colons in this experimental model, however, was not helpful in differentiating malignant from nonmalignant tissue. The implications of this study regarding the clinical application of HpD tumor fluorescence for the detection of colorectal carcinoma are discussed.

KW - colorectal carcinoma

KW - hematoporphyrin derivative

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Hematoporphyrin derivative: Quantitative uptake in dimethylhydrazine‐induced murine colorectal carcinoma

Abstract

Keywords

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