TY - JOUR
T1 - Geographically dispersed zoonotic tuberculosis in pre-contact South American human populations
AU - Vågene, Åshild J.
AU - Honap, Tanvi P.
AU - Harkins, Kelly M.
AU - Rosenberg, Michael S.
AU - Giffin, Karen
AU - Cárdenas-Arroyo, Felipe
AU - Leguizamón, Laura Paloma
AU - Arnett, Judith
AU - Buikstra, Jane E.
AU - Herbig, Alexander
AU - Krause, Johannes
AU - Stone, Anne C.
AU - Bos, Kirsten I.
N1 - Funding Information:
We thank Instituto Colombiano de Antropología e Historia (ICANH) and Instituto Nacional de Cultura del Perú (INC) for granting access to the samples and supporting this research. A permit for the Colombian samples was obtained from Autorización de Intervención Arqueológica (permit number 5304). We are immensely grateful to Fernando Montejo Gaitan who supported the authorization procedures in Colombia and to Sloan Williams, Nikki Clark, Don Rice and Geoffrey Conard who were part of the excavations at Estuquiña. We thank Ana Maria Boada, Jose Vicente Rodríguez Cuenca, Pedro Maria Arguello Garcia, Patricia Ramirez Nieto, Maria Angelica Garcia and Juan David Hernández Restrepo who supported this project at various points along the way. We are grateful to Guido Brandt for assistance with laboratory work, Michelle O’Reilly for graphical support, Ron Hübler for technical support and Elizabeth Nelson for thoughts and discussions on the manuscript. Funding was provided by the Max Planck Society (J.K., K.I.B.); European Research Council Starting Grants APGREID (J.K.) and CoDisEASe (805268) (K.I.B.); Social Sciences and Humanities Research Council of Canada postdoctoral fellowship grant (756-2011-501) (K.I.B.); National Science Foundation (BCS-1063939) (A.C.S., J.E.B) (BCS-1515163) (A.C.S, J.E.B, M.S.R); and The Wenner Gren Foundation for Anthropological Research (A.C.S).
Funding Information:
We thank Instituto Colombiano de Antropología e Historia (ICANH) and Instituto Nacional de Cultura del Perú (INC) for granting access to the samples and supporting this research. A permit for the Colombian samples was obtained from Autorización de Intervención Arqueológica (permit number 5304). We are immensely grateful to Fernando Montejo Gaitan who supported the authorization procedures in Colombia and to Sloan Williams, Nikki Clark, Don Rice and Geoffrey Conard who were part of the excavations at Estuquiña. We thank Ana Maria Boada, Jose Vicente Rodríguez Cuenca, Pedro Maria Arguello Garcia, Patricia Ramirez Nieto, Maria Angelica Garcia and Juan David Hernández Restrepo who supported this project at various points along the way. We are grateful to Guido Brandt for assistance with laboratory work, Michelle O’Reilly for graphical support, Ron Hübler for technical support and Elizabeth Nelson for thoughts and discussions on the manuscript. Funding was provided by the Max Planck Society (J.K., K.I.B.); European Research Council Starting Grants APGREID (J.K.) and CoDisEASe (805268) (K.I.B.); Social Sciences and Humanities Research Council of Canada postdoctoral fellowship grant (756-2011-501) (K.I.B.); National Science Foundation (BCS-1063939) (A.C.S., J.E.B) (BCS-1515163) (A.C.S, J.E.B, M.S.R); and The Wenner Gren Foundation for Anthropological Research (A.C.S).
Publisher Copyright:
© 2022, The Author(s).
PY - 2022/12
Y1 - 2022/12
N2 - Previous ancient DNA research has shown that Mycobacterium pinnipedii, which today causes tuberculosis (TB) primarily in pinnipeds, infected human populations living in the coastal areas of Peru prior to European colonization. Skeletal evidence indicates the presence of TB in several pre-colonial South and North American populations with minimal access to marine resources— a scenario incompatible with TB transmission directly from infected pinnipeds or their tissues. In this study, we investigate the causative agent of TB in ten pre-colonial, non-coastal individuals from South America. We reconstruct M. pinnipedii genomes (10- to 15-fold mean coverage) from three contemporaneous individuals from inland Peru and Colombia, demonstrating the widespread dissemination of M. pinnipedii beyond the coast, either through human-to-human and/or animal-mediated routes. Overall, our study suggests that TB transmission in the pre-colonial era Americas involved a more complex transmission pathway than simple pinniped-to-human transfer.
AB - Previous ancient DNA research has shown that Mycobacterium pinnipedii, which today causes tuberculosis (TB) primarily in pinnipeds, infected human populations living in the coastal areas of Peru prior to European colonization. Skeletal evidence indicates the presence of TB in several pre-colonial South and North American populations with minimal access to marine resources— a scenario incompatible with TB transmission directly from infected pinnipeds or their tissues. In this study, we investigate the causative agent of TB in ten pre-colonial, non-coastal individuals from South America. We reconstruct M. pinnipedii genomes (10- to 15-fold mean coverage) from three contemporaneous individuals from inland Peru and Colombia, demonstrating the widespread dissemination of M. pinnipedii beyond the coast, either through human-to-human and/or animal-mediated routes. Overall, our study suggests that TB transmission in the pre-colonial era Americas involved a more complex transmission pathway than simple pinniped-to-human transfer.
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U2 - 10.1038/s41467-022-28562-8
DO - 10.1038/s41467-022-28562-8
M3 - Article
C2 - 35256608
AN - SCOPUS:85125973779
SN - 2041-1723
VL - 13
JO - Nature communications
JF - Nature communications
IS - 1
M1 - 1195
ER -