TY - JOUR
T1 - Genetic influences on the interplay between obsessive-compulsive behavior symptoms and cannabis use during adolescence
AU - Kutzner, Jodi
AU - Elam, Kit
AU - Ha, Thao
N1 - Funding Information:
We gratefully acknowledge the contribution of the Project Alliance staff, Portland Public Schools, and the participating families. The research reported in this paper was supported by grants from the National Institute of Drug Abuse (TH, DA007031) and (KKE, DA042828, also supported by the Office of the Director and Office of Behavioral and Social Sciences Research). Additional support was given by the National Institute on Alcoholism and Alcohol Abuse (TH, AA022071). The content is solely the responsibility of the authors and does not necessarily reflect the official views of the National Institute on Drug Abuse, the National Institute on Alcoholism and Alcohol Abuse, or the Office of Behavioral and Social Sciences Research.
Funding Information:
We gratefully acknowledge the contribution of the Project Alliance staff, Portland Public Schools, and the participating families. The research reported in this paper was supported by grants from the National Institute of Drug Abuse (TH, DA007031) and (KKE, DA042828, also supported by the Office of the Director and Office of Behavioral and Social Sciences Research). Additional support was given by the National Institute on Alcoholism and Alcohol Abuse (TH, AA022071). The content is solely the responsibility of the authors and does not necessarily reflect the official views of the National Institute on Drug Abuse, the National Institute on Alcoholism and Alcohol Abuse, or the Office of Behavioral and Social Sciences Research.
Publisher Copyright:
© 2022 The Authors. Journal of Adolescence published by Wiley Periodicals LLC on behalf of Foundation for Professionals in Services to Adolescents.
PY - 2023/4
Y1 - 2023/4
N2 - Introduction: There are overlapping biological origins and behaviors associated with obsessive-compulsive symptoms (OCS) and cannabis use. There is also evidence that OCS and cannabis use are associated over time. Thus, we investigated polygenic predisposition for OCS as predictive of OCS and cannabis use from age 17 to 19. We hypothesized that greater genetic risk for OCS would predict both OCS and cannabis use. Methods: The current study used participants from the Project Alliance 1 study, a US-based sample, for whom genomic, OCS, and cannabis use data were available (n = 547). Polygenic risk scores (PRS) were formed via a meta-genome-wide association study on OCS and examined as a predictor of OCS and cannabis use at age 17 and 19. The sample was diverse (52.4% male; 45% European American, 30% African American, 14% multiracial, 5% Hispanic/Latino, 4% Asian American, and 2% other groups). Sensitivity analysis was performed by gender for European American and African American subsamples. Results: Across the whole sample, the greater polygenic risk for OCS was negatively associated with cannabis use at age 17 and positively associated with OCS at 19. Cannabis use at age 17 was positively associated with OCS at age 19. The association between polygenic risk for OCS and cannabis use at age 17 was replicated in European American males, whereas the association between cannabis use at age 17 and OCS at age 19 was replicated in African American males. Conclusions: Cannabis use may exacerbate OCS through adolescence, and genetic predisposition for OCS may be associated with lower cannabis use in efforts to avoid exacerbation of OCS.
AB - Introduction: There are overlapping biological origins and behaviors associated with obsessive-compulsive symptoms (OCS) and cannabis use. There is also evidence that OCS and cannabis use are associated over time. Thus, we investigated polygenic predisposition for OCS as predictive of OCS and cannabis use from age 17 to 19. We hypothesized that greater genetic risk for OCS would predict both OCS and cannabis use. Methods: The current study used participants from the Project Alliance 1 study, a US-based sample, for whom genomic, OCS, and cannabis use data were available (n = 547). Polygenic risk scores (PRS) were formed via a meta-genome-wide association study on OCS and examined as a predictor of OCS and cannabis use at age 17 and 19. The sample was diverse (52.4% male; 45% European American, 30% African American, 14% multiracial, 5% Hispanic/Latino, 4% Asian American, and 2% other groups). Sensitivity analysis was performed by gender for European American and African American subsamples. Results: Across the whole sample, the greater polygenic risk for OCS was negatively associated with cannabis use at age 17 and positively associated with OCS at 19. Cannabis use at age 17 was positively associated with OCS at age 19. The association between polygenic risk for OCS and cannabis use at age 17 was replicated in European American males, whereas the association between cannabis use at age 17 and OCS at age 19 was replicated in African American males. Conclusions: Cannabis use may exacerbate OCS through adolescence, and genetic predisposition for OCS may be associated with lower cannabis use in efforts to avoid exacerbation of OCS.
KW - adolescence
KW - cannabis
KW - obsessive-compulsive symptoms
KW - polygenic
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U2 - 10.1002/jad.12125
DO - 10.1002/jad.12125
M3 - Article
C2 - 36443914
AN - SCOPUS:85142883806
SN - 0140-1971
VL - 95
SP - 427
EP - 436
JO - Journal of Adolescence
JF - Journal of Adolescence
IS - 3
ER -