TY - JOUR
T1 - Gene set enrichment analysis to create polygenic scores
T2 - a developmental examination of aggression
AU - Elam, Kit K.
AU - Clifford, Sierra
AU - Shaw, Daniel S.
AU - Wilson, Melvin N.
AU - Lemery-Chalfant, Kathryn
N1 - Funding Information:
We thank the families for their participation and the research staff for their help with data collection and management. This research was supported by grants from the National Institute on Drug Abuse (DA022773, DA023245, and DA036832) awarded to Daniel S. Shaw and Melvin N. Wilson and the National Institutes of Health: the National Institute on Drug Abuse and Office of Behavioral and Social Sciences Research (K01DA042828) awarded to Kit K. Elam.
Publisher Copyright:
© 2019, The Author(s).
PY - 2019/12/1
Y1 - 2019/12/1
N2 - Previous approaches for creating polygenic risk scores (PRSs) do not explicitly consider the biological or developmental relevance of the genetic variants selected for inclusion. We applied gene set enrichment analysis to meta-GWAS data to create developmentally targeted, functionally informed PRSs. Using two developmentally matched meta-GWAS discovery samples, separate PRSs were formed, then examined in time-varying effect models of aggression in a second, longitudinal sample of children (n = 515, 49% female) in early childhood (2–5 years old), and middle childhood (7.5–10.5 years old). Functional PRSs were associated with aggression in both the early and middle childhood models.
AB - Previous approaches for creating polygenic risk scores (PRSs) do not explicitly consider the biological or developmental relevance of the genetic variants selected for inclusion. We applied gene set enrichment analysis to meta-GWAS data to create developmentally targeted, functionally informed PRSs. Using two developmentally matched meta-GWAS discovery samples, separate PRSs were formed, then examined in time-varying effect models of aggression in a second, longitudinal sample of children (n = 515, 49% female) in early childhood (2–5 years old), and middle childhood (7.5–10.5 years old). Functional PRSs were associated with aggression in both the early and middle childhood models.
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U2 - 10.1038/s41398-019-0513-7
DO - 10.1038/s41398-019-0513-7
M3 - Article
C2 - 31477688
AN - SCOPUS:85071776434
SN - 2158-3188
VL - 9
JO - Translational Psychiatry
JF - Translational Psychiatry
IS - 1
M1 - 212
ER -