TY - JOUR
T1 - Gene set enrichment analysis to create polygenic scores
T2 - a developmental examination of aggression
AU - Elam, Kit K.
AU - Clifford, Sierra
AU - Shaw, Daniel S.
AU - Wilson, Melvin N.
AU - Lemery-Chalfant, Kathryn
N1 - Publisher Copyright:
© 2019, The Author(s).
PY - 2019/12/1
Y1 - 2019/12/1
N2 - Previous approaches for creating polygenic risk scores (PRSs) do not explicitly consider the biological or developmental relevance of the genetic variants selected for inclusion. We applied gene set enrichment analysis to meta-GWAS data to create developmentally targeted, functionally informed PRSs. Using two developmentally matched meta-GWAS discovery samples, separate PRSs were formed, then examined in time-varying effect models of aggression in a second, longitudinal sample of children (n = 515, 49% female) in early childhood (2–5 years old), and middle childhood (7.5–10.5 years old). Functional PRSs were associated with aggression in both the early and middle childhood models.
AB - Previous approaches for creating polygenic risk scores (PRSs) do not explicitly consider the biological or developmental relevance of the genetic variants selected for inclusion. We applied gene set enrichment analysis to meta-GWAS data to create developmentally targeted, functionally informed PRSs. Using two developmentally matched meta-GWAS discovery samples, separate PRSs were formed, then examined in time-varying effect models of aggression in a second, longitudinal sample of children (n = 515, 49% female) in early childhood (2–5 years old), and middle childhood (7.5–10.5 years old). Functional PRSs were associated with aggression in both the early and middle childhood models.
UR - http://www.scopus.com/inward/record.url?scp=85071776434&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85071776434&partnerID=8YFLogxK
U2 - 10.1038/s41398-019-0513-7
DO - 10.1038/s41398-019-0513-7
M3 - Article
C2 - 31477688
AN - SCOPUS:85071776434
SN - 2158-3188
VL - 9
JO - Translational Psychiatry
JF - Translational Psychiatry
IS - 1
M1 - 212
ER -