Further Evidence for BRCA1 Communication with the Inactive X Chromosome

Daniel P. Silver, Stoil D. Dimitrov, Jean Feunteun, Rebecca Gelman, Ronny Drapkin, Shihua D. Lu, Elena Shestakova, Soundarapandian Velmurugan, Nicholas DeNunzio, Serban Dragomir, Jessica Mar, Xiaoling Liu, Sven Rottenberg, Jos Jonkers, Shridar Ganesan, David M. Livingston

Research output: Contribution to journalLetterpeer-review

69 Scopus citations


BRCA1, a breast and ovarian cancer-suppressor gene, exerts tumor-suppressing functions that appear to be associated, at least in part, with its DNA repair, checkpoint, and mitotic regulatory activities. Earlier work from our laboratory also suggested an ability of BRCA1 to communicate with the inactive X chromosome (Xi) in female somatic cells (Ganesan et al., 2002). Xiao et al. (2007) (this issue of Cell) have challenged this conclusion. Here we discuss recently published data from our laboratory and others and present new results that, together, provide further support for a role of BRCA1 in the regulation of XIST concentration on Xi in somatic cells.

Original languageEnglish (US)
Pages (from-to)991-1002
Number of pages12
Issue number5
StatePublished - Mar 9 2007
Externally publishedYes

ASJC Scopus subject areas

  • General Biochemistry, Genetics and Molecular Biology


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