TY - JOUR
T1 - Further Evidence for BRCA1 Communication with the Inactive X Chromosome
AU - Silver, Daniel P.
AU - Dimitrov, Stoil D.
AU - Feunteun, Jean
AU - Gelman, Rebecca
AU - Drapkin, Ronny
AU - Lu, Shihua D.
AU - Shestakova, Elena
AU - Velmurugan, Soundarapandian
AU - DeNunzio, Nicholas
AU - Dragomir, Serban
AU - Mar, Jessica
AU - Liu, Xiaoling
AU - Rottenberg, Sven
AU - Jonkers, Jos
AU - Ganesan, Shridar
AU - Livingston, David M.
N1 - Funding Information:
We wish to extend our thanks to J. Lawrence and G. Pageau for helpful discussions and for sharing the results of their BRCA1/heterochromatin association experiments prior to publication. We would also like to acknowledge the contributions of S. Pathania and B. Liu (DFCI) for help with scoring photomicrographs; K. McKinney and M. Brown (DFCI) for critical reading of the manuscript; L. van Deemter (NKI) for expert help with generating mouse tumor lines; and M. Yao (CINJ), S. Landini (DFCI), and E. Briggs (DFCI) for expert technical help. We also thank J. Lee for providing a murine Xist plasmid. D.P.S. wishes to acknowledge funding from the Robert and Deborah First Family Foundation, S.D.D. from an NSF-NATO Postdoctoral Research Fellowship, J.F. from ARC, S.R. from the Swiss National Science Foundation and the Schweizerische Stiftung für medizinisch-biologische Stipendien, X.L. and J.J. from the Dutch Cancer Society, S.G. from the NIH and the UMDNJ Foundation, and D.M.L. from the National Cancer Institute. D.M.L. is a research grantee of and scientific consultant to the Novartis Institute for Biomedical Research.
PY - 2007/3/9
Y1 - 2007/3/9
N2 - BRCA1, a breast and ovarian cancer-suppressor gene, exerts tumor-suppressing functions that appear to be associated, at least in part, with its DNA repair, checkpoint, and mitotic regulatory activities. Earlier work from our laboratory also suggested an ability of BRCA1 to communicate with the inactive X chromosome (Xi) in female somatic cells (Ganesan et al., 2002). Xiao et al. (2007) (this issue of Cell) have challenged this conclusion. Here we discuss recently published data from our laboratory and others and present new results that, together, provide further support for a role of BRCA1 in the regulation of XIST concentration on Xi in somatic cells.
AB - BRCA1, a breast and ovarian cancer-suppressor gene, exerts tumor-suppressing functions that appear to be associated, at least in part, with its DNA repair, checkpoint, and mitotic regulatory activities. Earlier work from our laboratory also suggested an ability of BRCA1 to communicate with the inactive X chromosome (Xi) in female somatic cells (Ganesan et al., 2002). Xiao et al. (2007) (this issue of Cell) have challenged this conclusion. Here we discuss recently published data from our laboratory and others and present new results that, together, provide further support for a role of BRCA1 in the regulation of XIST concentration on Xi in somatic cells.
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U2 - 10.1016/j.cell.2007.02.025
DO - 10.1016/j.cell.2007.02.025
M3 - Letter
C2 - 17350581
AN - SCOPUS:33847411837
SN - 0092-8674
VL - 128
SP - 991
EP - 1002
JO - Cell
JF - Cell
IS - 5
ER -