Fibroblast functionality on novel Ti30Ta nanotube array

Patricia Capellato, Barbara S. Smith, Ketul C. Popat, Ana P.R.Alves Claro

Research output: Contribution to journalArticlepeer-review

29 Scopus citations


In this study, the mechanical substrate and topographical surface properties of anodized Ti30Ta alloy were investigated using scanning electron microscopy (SEM), energy-dispersive spectroscopy (EDS) and contact angle measurement. The anodization process was performed in an electrolyte solution containing HF (48%) and H 2SO 4 (98%) in the volumetric ratios 1:9 with the addition of 5% dimethyl sulfoxide (DMSO) at 15 V, 25 V and 35 V for 20 and 40 min, producing a nanotube architecture when anodized at 35 V for 40 min. Human dermal fibroblasts (HDF, neonatal) were utilized to evaluate the biocompatibility of Ti30Ta nanotubes and Ti30Ta alloy after 1 and 3 days of culture. Cellular adhesion, proliferation, viability, cytoskeletal organization and morphology were investigated using fluorescence microscope imaging, biochemical assay and SEM imaging respectively. The results presented identify altered material properties and improved cellular interaction on Ti30Ta nanotubes as compared to Ti30 Ta alloy.

Original languageEnglish (US)
Pages (from-to)2060-2067
Number of pages8
JournalMaterials Science and Engineering C
Issue number7
StatePublished - Oct 1 2012
Externally publishedYes


  • Anodization
  • Human dermal fibroblasts
  • Ti30Ta nanotubes

ASJC Scopus subject areas

  • Materials Science(all)
  • Condensed Matter Physics
  • Mechanics of Materials
  • Mechanical Engineering


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