TY - JOUR
T1 - Exposure to environmentally relevant concentrations of Bisphenol-A linked to loss of visual lateralization in adult zebrafish (Danio rerio)
AU - Suriyampola, Piyumika S.
AU - Huang, Alexander J.
AU - Lopez, Melissa
AU - Conroy-Ben, Otakuye
AU - Martins, Emília P.
N1 - Publisher Copyright:
© 2024
PY - 2024/3
Y1 - 2024/3
N2 - Weak, but environmentally relevant concentrations of contaminants can have subtle, yet important, impacts on organisms, which are often overlooked due to the lack of acute impacts and the timing of exposure. Thus, recognizing simple, non-invasive markers of contamination events is essential for early detection and addressing the effects of exposure to weak environmental contaminants. Here, we tested whether exposure to an environmentally relevant concentration of Bisphenol-A (BPA), a common and persistent contaminant in aquatic systems, affects the lateralization of adult zebrafish (Danio rerio), a widely used model organism in ecotoxicology. We found that 73.5% of adult zebrafish displayed a left-side bias when they approached a visual cue, but that those exposed to weak BPA (0.02 mg/L) for 7 days did not exhibit laterality. Only 47.1% displayed a left-side bias. We found no differences in activity level and visual sensitivity, motor and sensory mechanisms, that regulate lateralized responses and that were unaffected by weak BPA exposure. These findings indicate the reliability of laterality as a simple measure of contaminant exposure and for future studies of the detailed mechanisms underlying subtle and complex behavioral effects to pollutants.
AB - Weak, but environmentally relevant concentrations of contaminants can have subtle, yet important, impacts on organisms, which are often overlooked due to the lack of acute impacts and the timing of exposure. Thus, recognizing simple, non-invasive markers of contamination events is essential for early detection and addressing the effects of exposure to weak environmental contaminants. Here, we tested whether exposure to an environmentally relevant concentration of Bisphenol-A (BPA), a common and persistent contaminant in aquatic systems, affects the lateralization of adult zebrafish (Danio rerio), a widely used model organism in ecotoxicology. We found that 73.5% of adult zebrafish displayed a left-side bias when they approached a visual cue, but that those exposed to weak BPA (0.02 mg/L) for 7 days did not exhibit laterality. Only 47.1% displayed a left-side bias. We found no differences in activity level and visual sensitivity, motor and sensory mechanisms, that regulate lateralized responses and that were unaffected by weak BPA exposure. These findings indicate the reliability of laterality as a simple measure of contaminant exposure and for future studies of the detailed mechanisms underlying subtle and complex behavioral effects to pollutants.
KW - Bisphenol-A
KW - Environmentally relevant concentration
KW - Lateralization
KW - Sub-lethal levels
KW - Zebrafish
UR - http://www.scopus.com/inward/record.url?scp=85186751814&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85186751814&partnerID=8YFLogxK
U2 - 10.1016/j.aquatox.2024.106862
DO - 10.1016/j.aquatox.2024.106862
M3 - Article
C2 - 38359500
AN - SCOPUS:85186751814
SN - 0166-445X
VL - 268
JO - Aquatic Toxicology
JF - Aquatic Toxicology
M1 - 106862
ER -